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a b s t r a c tWe consider a Distributed Assembly Permutation Flowshop Scheduling Problem with sequence dependent setup times and the objective of makespan minimization. The problem consists of two stages, production and assembly. The first stage comprises f identical factories, where each factory is a flowshop that produces jobs which are later assembled into final products through an identical assembly program in a second assembly stage made by a single machine. Both stages have sequence dependent setup times. This is a realistic and complex problem and therefore, we propose two simple heuristics and two metaheuristics to solve it. A complete calibration and analysis through a Design Of Experiments (DOE) approach is carried out. In the process, important knowledge of the studied problem is obtained as well as some simplifications for the powerful Iterated Greedy methodology which results in a simpler approach with less parameters. Finally, the performance of the proposed methods is compared through extensive computational and statistical experiments.

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