Mitral regurgitation is a source of significant morbidity and mortality with growing prevalence in an increasingly ageing population. The development of reparative percutaneous techniques allows offering treatment to patients ineligible for surgery. The mitral valve is a complex structure and these procedures are limited by anatomical variability and technical complexity. The most established mitral valve repair technique currently is the MitraClip, which requires a careful preoperative evaluation of the mitral valve apparatus to assess the patient's suitability for the intervention, where echocardiography plays an essential role.
Background: Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS); however, transcatheter aortic valve implantation (TAVI) may positively affect LV mechanics. Assessed herein is the performance of the SAPIEN 3 transcatheter heart valve (THV) and the effect of TAVI on LV function recovery, as assessed by global longitudinal strain (GLS). Methods: A subset of patients from the SOURCE 3 registry (n = 276) from 16 European centers received SAPIEN 3 balloon-expandable THV. Echocardiography was performed at baseline, postprocedure, and at 1 year, including assessment of GLS using standard two-dimensional images, and was analyzed in a core laboratory. Paired analyses between baseline and discharge, baseline and at 1 year were conducted. Results: Hemodynamic parameters were improved after TAVI and sustained to 1 year. At 1 year, the rate of moderate to severe paravalvular leaks (PVL), and moderate to severe mitral and tricuspid regurgitations were 1.
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