Let-7a-5p, miR-142-3p, miR-145-5p and miR-454-3p are differentially expressed in LMNA carriers. A composite score based on these miRNAs is a biomarker of mutations in the LMNA gene. This miRNA signature can be associated with the pathophysiology of familial DCM. The circulating miRNA profile can assist in the diagnosis of familial DCM.
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