To know the electrophysiological pattern of peripheral neuropathy in leprosy. Methods: We recruited consecutive, newly diagnosed leprosy patients without leprosy reactions for the study. Sensory and motor nerve conduction studies were carried out in the neuro-electrophysiology laboratory. Motor studies were done bilaterally for the median, ulnar, radial, common peroneal and tibial nerves. Likewise, sensory studies were done for the median, ulnar, radial and sural nerves. All findings were recorded on a preset pro-forma. Results: Seventy-four patients were enrolled. The mean age was 35•09^14•92 years, ranging between 12 and 73 years. The median duration of illness was 7•5 (3•75-15) months. The male to female ratio was 2:1. Almost half of the patients (43%) had impaired nerve conduction at the time of diagnosis. Sensory neuropathy was more frequent (32%) compared to motor (20%). Sensory-motor axonal type was the commonest (37•5%) pattern of peripheral neuropathy. Ulnar (24%) and sural (22%) nerves were the most commonly affected motor and sensory nerves respectively. Amplitude was the most commonly affected parameter of both the sensory nerve action potential (SNAP) and the compound motor action potential (CMAP) and it was impaired in 100% of nerves having impaired nerve conduction. Conclusion: Sensory-motor axonal type was the commonest pattern of peripheral neuropathy in leprosy. From our study, amplitude can be considered as the most informative parameter, but further studies are recommended.
INTRODUCTIONPregnancy causes altered function of excitable membranes such as muscle and nerve, due to hormonal changes and edema.1 Carpal tunnel syndrome (CTS) is a frequent complication of pregnancy. The pathology involves the compression of the median nerve passing through the carpal tunnel in the hand. Its prevalence is as high as 62% in some populations during third trimester of pregnancy.2 Available published research points towards various causes of CTS in pregnant woman as influence of hormonal changes, neural oedema, anatomically narrow carpal tunnel etc.2,3 However increase incidence of CTS in woman on regular hormonal contraception and cessation of CTS symptoms in post-partum period suggest the hormonal theory to be true. [2][3][4] Thus to supplement this hypothesis and association of nerve conduction abnormalities with pregnancy, we focused on this research. We failed to find any studies focusing on the issue of nerve conduction during pregnancy, in India. Thus present study aims to see the difference between nerve conduction parameters viz. motor and sensory conduction, in pregnant and non-pregnant women. Our objective was to study the electrophysiological changes in median and ulnar nerve conduction during pregnancy, who have no symptoms of carpal tunnel syndrome during the third trimester in our local population. METHODSThis was a cross-sectional research carried out in randomly selected 30 pregnant women, of any age, in 28-ABSTRACT Background: Pregnancy causes altered function of excitable membranes such as muscle and nerve, due to hormonal changes and edema. We failed to find any studies focusing on the issue of nerve conduction during pregnancy, in India. Thus present study aims to see the difference between nerve conduction parameters viz. motor and sensory conduction, in pregnant and non-pregnant women. Methods: This was a cross-sectional study carried out in randomly selected 30 pregnant women, of any age, in 28-40 weeks of gestation and age matched non-pregnant controls. We studied distal motor latency, compound muscle action potential amplitude, motor nerve conduction velocity, F-minimum latency, sensory latency, sensory nerve action potential amplitude and sensory nerve conduction velocity in bilateral median and ulnar nerves using Aleron-RMS. Results: Present study found no statistically significant difference between motor and sensory conduction of above said nerves in pregnant and nonpregnant women, except F minimum latency of left median nerve in pregnant women and sensory latency of left ulnar nerve in non-pregnant women were prolonged significantly (p<0.05). Conclusions: All motor and sensory parameters of bilateral median and ulnar nerves were normal as compared to non-pregnant controls.
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