An elevated pretreatment NLR is a prognostic marker for head and neck cancer. It represents a simple and easily obtained marker that could be used to stratify groups of high-risk patients who might benefit from adjuvant therapy.
Surveillance is a valid alternative to immediate retroperitoneal lymph node dissection in patients with clinical stage I NSGCTT but should be recommended only under the close supervision of physicians experienced in the diagnosis and treatment of testicular cancer.
An elevated LMR may be an indicator of favorable prognosis in HNC. However, our results should be interpreted with some degree of caution due to the retrospective nature of cohort studies. Further research with high-quality prospective studies is needed to confirm the effect of LMR in HNC prognosis.
The aim of this systematic review and meta-analysis was to investigate the prognostic utility of the platelet-to-lymphocyte ratio (PLR) in head and neck cancer. Medline (via PubMed), EMBASE, Scopus, and the Cochrane Library databases were searched from their inception to May 2017 for relevant literature. A systematic review and meta-analysis were performed to generate the pooled hazard ratios (HR) for overall survival (OS) and disease-specific survival (DSS). The study was conducted in accordance with the Cochrane Handbook and PRISMA guidelines. Risk of bias was assessed using the QUIPS tool. The logarithm of the HR with standard error was used as the primary summary statistic. Heterogeneity was assessed using Cochran’s Q and Higgins’ I<sup>2</sup>. A total of 13 studies were included in the final analysis, combining data from 4,541 patients. The results demonstrated that an elevated PLR was significantly associated with poorer OS [HR 1.85, 95% CI 1.35–2.52, <i>p</i> < 0.00001] and DSS [HR 1.57, 95% CI 1.25–1.97, <i>p</i> < 0.0001]. Significant heterogeneity was detected for the pooled end points. Subgroup analysis demonstrated reduction of heterogeneity by controlling for sample size and cutoff value. 95% prediction intervals showed wide ranges crossing the null threshold.
Background
The American Joint Committee on Cancer (AJCC) Precision Medicine Core (PMC) has recognized the need for more personalized probabilistic predictions above the “TNM” staging system and has recently released a checklist of inclusion and exclusion criteria for evaluating prognostic models.
Methods
A systematic review of articles in which nomograms were created for head and neck cancer (HNC) was carried out according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The AJCC PMC criteria were used to score the individual studies.
Results
Forty‐four studies were included in the final qualitative analysis. The mean number of inclusion criteria met was 9.3 out of 13, and the mean number of exclusion criteria met was 2.1 out of 3. Studies were generally of high quality, but no single study fulfilled all of the AJCC PMC criteria.
Conclusion
This is the first study to utilize the AJCC checklist to comprehensively evaluate the published prognostic nomograms in HNC. Future studies should attempt to adhere to the AJCC PMC criteria. Recommendations for future research are given.
Summary
The AJCC recently released a set of criteria to grade the quality of prognostic cancer models. In this study, we grade all published nomograms for head and neck cancer according to the new guidelines.
Background
: Traditional journal clubs have been limited by the geography of participants. Web based modalities and social media platforms are now being used to bridge this barrier. Medical education journal club, given the diversity of its community would lend well to these platforms. To date there is very little published regarding online medical education journal clubs.
Objective
: To bridge geographical barriers; enhance interdisciplinary and interprofessional discussion and collaboration; and to provide opportunities for continuing medical education and faculty development; a monthly synchronous medical education journal club was created for faculty.
Design/Methods
: From April 2015 to November 2016, 11 online journal clubs were held for the faculty at Northwell Health and the Barbara and Donald Zucker School of Medicine at Hofstra/Northwell (Zucker SOM). All articles picked were relevant to medical education and participants were from multiple disciplines.
Results
: 74% of respondent participants agreed that the content covered during the sessions would positively impact personal and/or professional life and 58% of respondents reported that their overall knowledge/skill level changed positively.
Conclusions
: On-line medical education journal club can provide a valuable opportunity for continuing education and faculty development for both the participant and the presenter.
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