Rheumatoid meningitis (RM) is a rare central nervous system (CNS) manifestation of rheumatoid arthritis (RA) with a wide spectrum of symptoms. We present a review of the literature with a rare illustrative case of a 61-year-old man with a history of seropositive rheumatoid arthritis (RA) who presented headaches, stroke-like symptoms and seizures. MRI revealed the leptomeningeal enhancement in the right hemisphere. As cerebromeningeal fluid showed increased level of protein and was positive for Candida mannan, the initial clinical diagnosis was fungal meningitis. Despite the antifungal treatment the patient's clinical condition did not improve. Detailed laboratory, radiologic and histopathological diagnostics enabled the diagnosis of RM. In conclusion is worth to highlight that presentation of RM is variable and complex, diagnosing it is a big dilemma which is why it must be considered in the differential in a patient with long-standing seropositive RA.
or myeloperoxidase (MPO). As AAV predominantly involve small vessels (arteries, arterioles, venules, and veins), any organ of the body can be affected. These vasculitides typically involve the upper respiratory tract, lungs, and kidneys, but skin, nervous system, gastrointestinal tract, and eye may also be affected. Although INTROduCTION Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of diseases characterized by necrotizing inflammation of small vessels that leads to damage and dysfunction of the supplied organs. 1 They are associated with the presence of specific antibodies against proteinase 3 (PR3)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.