Bi2.5Y0.5Fe5O12 and Bi3Fe5O12 thin films were prepared on Gd3Ga5O12 substrates using a metal organic decomposition (MOD) method as magneto-optical indicators (MOI) to visualize the distribution of magnetic flux. Their structural and magneto-optical properties were studied. The Faraday rotations of Bi2.5Y0.5Fe5O12 and Bi3Fe5O12 thin films were 15.5 m/degrees at a wavelength of 524 nm for the former and 23.0 m/degrees at 530 nm for the latter. We found that these films prepared by MOD were suitable for MOI, because of their large Faraday rotation, in-plane magnetic anisotropy, and extinct magnetic domain structures.
Background and purposeOutcome after ligament reconstruction or tendon repair depends on secure tendon-to-bone healing. Increased osteoclastic activity resulting in local bone loss may contribute to delayed healing of the tendon–bone interface. The objective of this study was to evaluate the effect of the bisphosphonate zoledronic acid (ZA) on tendon-to-bone healing.MethodsWistar rats (n = 92) had their right Achilles tendon cut proximally, pulled through a bone tunnel in the distal tibia and sutured anteriorly. After 1 week animals were randomized to receive a single dose of ZA (0.1 mg/kg IV) or control. Healing was evaluated at 3 and 6 weeks by mechanical testing, dual-energy X-ray absorptiometry and histology including immunohistochemical staining of osteoclasts.ResultsZA treatment resulted in 19% (95% CI 5–33%) lower pullout strength and 43% (95% CI 14–72%) lower stiffness of the tendon–bone interface, compared with control (2-way ANOVA; p = 0.009, p = 0.007). Administration of ZA did not affect bone mineral density (BMD) or bone mineral content (BMC). Histological analyses did not reveal differences in callus formation or osteoclasts between the study groups.InterpretationZA reduced pullout strength and stiffness of the tendon–bone interface. The study does not provide support for ZA as adjuvant treatment in tendon-to-bone healing.
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