Large-eddy simulations (LES) based on scale-selective implicit filtering are carried out in order to study the effect of nozzle pressure ratios on the characteristics of highly underexpanded jets. Pressure ratios ranging from 4.5 to 8.5 with Reynolds numbers of the order 75 000-140 000 are considered. The studied configuration agrees well with the classical picture of the structure of highly underexpanded jets. Similarities and differences between simulation and experiments are discussed by comparing the concentration field structures from LES and planar laser induced fluorescence data. The transient stages, leading eventually to the highly underexpanded state, are visualized and investigated in terms of a phase diagram revealing the shock speeds and duration of the transient stages. For the studied nozzle pressure ratio range, the Mach disk dimensions are found to be in good agreement with literature data and experimental observations. It is observed how the nozzle pressure ratio influences the Mach disk width, and thereby the slip line separation, which leads to co-annular jets with inner and outer shear layers at higher pressure ratios. The improved mixing with increasing pressure ratio is demonstrated by the probability density functions of the concentration. The coherent structures downstream of the Mach disk are identified using proper orthogonal decomposition (POD). The structures indicate a helical mode originating from the shear layers of the jet. Despite the relatively low energy content of the dominant POD modes, the frequencies of the POD time coefficients explain the dominant frequencies in the pressure fluctuation spectra. C

Abstract-Rendering a face recognition system robust is vital in order to safeguard it against spoof attacks carried out by using printed pictures of a victim (also known as print attack) or a replayed video of the person (replay attack). A key property in distinguishing a live, valid access from printed media or replayed videos is by exploiting the information dynamics of the video content, such as blinking eyes, moving lips, and facial dynamics. We advance the state of the art in facial anti-spoofing by applying a recently developed algorithm called Dynamic Mode Decomposition (DMD) as a general-purpose, entirely data-driven approach to capture the above liveness cues. We propose a classification pipeline consisting of DMD, Local Binary Patterns (LBP), and Support Vector Machines (SVM) with a histogram intersection kernel. A unique property of DMD is its ability to conveniently represent the temporal information of the entire video as a single image with the same dimensions as those images contained in the video. The pipeline of DMD+LBP+SVM proves to be efficient, convenient to use, and effective. In fact only the spatial configuration for LBP needs to be tuned. The effectiveness of the methodology was demonstrated using three publicly available databases: print-attack, replay-attack, and CASIA-FASD, attaining comparable results with the state of the art, following the respective published experimental protocols.

The Open Targets Platform (https://platform.opentargets.org/) is an open source resource to systematically assist drug target identification and prioritisation using publicly available data. Since our last update, we have reimagined, redesigned, and rebuilt the Platform in order to streamline data integration and harmonisation, expand the ways in which users can explore the data, and improve the user experience. The gene–disease causal evidence has been enhanced and expanded to better capture disease causality across rare, common, and somatic diseases. For target and drug annotations, we have incorporated new features that help assess target safety and tractability, including genetic constraint, PROTACtability assessments, and AlphaFold structure predictions. We have also introduced new machine learning applications for knowledge extraction from the published literature, clinical trial information, and drug labels. The new technologies and frameworks introduced since the last update will ease the introduction of new features and the creation of separate instances of the Platform adapted to user requirements. Our new Community forum, expanded training materials, and outreach programme support our users in a range of use cases.

Abstract

Europe PMC (https://europepmc.org) is a database of research articles, including peer reviewed full text articles and abstracts, and preprints - all freely available for use via website, APIs and bulk download. This article outlines new developments since 2017 where work has focussed on three key areas: (i) Europe PMC has added to its core content to include life science preprint abstracts and a special collection of full text of COVID-19-related preprints. Europe PMC is unique as an aggregator of biomedical preprints alongside peer-reviewed articles, with over 180 000 preprints available to search. (ii) Europe PMC has significantly expanded its links to content related to the publications, such as links to Unpaywall, providing wider access to full text, preprint peer-review platforms, all major curated data resources in the life sciences, and experimental protocols. The redesigned Europe PMC website features the PubMed abstract and corresponding PMC full text merged into one article page; there is more evident and user-friendly navigation within articles and to related content, plus a figure browse feature. (iii) The expanded annotations platform offers ∼1.3 billion text mined biological terms and concepts sourced from 10 providers and over 40 global data resources.