Additive manufacturing (AM) also known as 3D printing is a technology that builds three-dimensional (3-D) solid objects. Customized 3D objects with complex geometries and integrated functional designs can be created using 3D printing. A comprehensive review of AM process with emphasis on recent advances achieved by various researchers and industries is discussed. Summary of each 3D printing technology capabilities, advantages and limitations is provided. This article reviews significant developments of 3D printing applications in different fields such as electronics, medical industry, aerospace, automobile, construction, fashion and food industry.
Microneedles are micron-sized devices that are used for the transdermal administration of a wide range of active pharmaceutics substances with minimally invasive pain. In the past decade, various additive manufacturing technologies have been used for the fabrication of microneedles; however, they have limitations due to material compatibility and bioavailability and are time-consuming and expensive processes. Additive manufacturing (AM), which is popularly known as 3D-printing, is an innovative technology that builds three-dimensional solid objects (3D). This article provides a comprehensive review of the different 3D-printing technologies that have the potential to revolutionize the manufacturing of microneedles. The application of 3D-printed microneedles in various fields, such as drug delivery, vaccine delivery, cosmetics, therapy, tissue engineering, and diagnostics, are presented. This review also enumerates the challenges that are posed by the 3D-printing technologies, including the manufacturing cost, which limits its viability for large-scale production, the compatibility of the microneedle-based materials with human cells, and concerns around the efficient administration of large dosages of loaded microneedles. Furthermore, the optimization of microneedle design parameters and features for the best printing outcomes is of paramount interest. The Food and Drug Administration (FDA) regulatory guidelines relating to the safe use of microneedle devices are outlined. Finally, this review delineates the implementation of futuristic technologies, such as artificial intelligence algorithms, for 3D-printed microneedles and 4D-printing capabilities.
Abstract:The fabrication of electronic components in three-dimensional space is critical for building multifunctional devices. Traditional manufacturing approaches are limited to building planar device configurations. In order to address this limitation, our group has developed a novel hybrid additive manufacturing process that can deposit multi-material patterns on conformal substrates. This direct-write approach involves the combination of microextrusion, pico jet and laser systems. A multi-axis robot was employed to deposit slurries and colloids of conductive materials on different substrates. Fine deposition of the slurries was achieved by tuning the process parameters such as deposition line speed, extrusion pressure, curing temperature, Z-height, laser beam spot, material type and laser intensity. Precise deposition of the medium viscous colloidal liquids was achieved by pico jet unit. Sintering of the micro/nano particles was achieved using a fiber optic laser system and micro wave furnace. The conductance of the deposited electrical trace varied based on the material type and trace cross-section area. This research lays the foundation to build a three-dimensional hierarchy of electronic components. By embedding components at various depths and orientations complex electronic circuitry with versatile material compositions and design flexibility can be fabricated in situ.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.