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1-Hexenesulphonic acid sodium salt as catalyst for green synthesis of bis(indol-3-yl)methanes was described. The reaction of indole with various aldehydes in water using ultrasound irradiation at ambient temperature for appropriate time using 1-hexenesulphonic acid sodium salt furnish the desired product in good to excellent yield. Utilization of aqueous medium, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.

IVd) exhibit good analgesic and antiinflammatory inhibition and are almost equipotent to the standard compound. -(JOSHI, R. S.; MANDHANE, P. G.; DIWAKAR, S. D.; DABHADE, S. K.; GILL*, C. H.; Bioorg. Med.

In search for a new antibacterial agent with improved antimicrobial spectrum and potency, we designed and synthesized a series of novel 3‐((Z)‐2‐(5‐methyl‐1,2,4‐oxadiazol‐3‐yl)‐2‐(4‐nitrophenyl)vinyl)‐4H‐chromen‐4‐ones 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h by convergent synthesis approach. All the synthesized compounds were assayed for their in vitro antibacterial activities against gram‐negative and gram‐positive bacteria. The preliminary structure‐activity relationship to elucidate the essential structure requirements for the antimicrobial activity has been described. J. Heterocyclic Chem., (2011).

Benzopyran derivatives R 0350Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl)vinyl)-4H-chromen--4-ones as Novel anti-MRSA Agents: Synthesis, SAR, and in vitro Assessment.-Two routes to chromenones (V) are designed, a linear approach and a convergent one. In a convergent fashion, nitrobenzylcyanide (II) is converted into the tetrazole derivative (III) by the Sharpless method. Condensing (III) with formylchromones (IV) afford the title compounds (V) selectively as (Z)-regioisomers. In the linear fashion, all attempts to convert the cyano group into the tetrazole moiety fail. A preliminary structure-activity relationship assay reveals that compounds (V) possess activity against methicillin-resistant S. aureus as well as against a panel of pathogenic bacterial strains. -(DIWAKAR, S. D.; BHAGWAT, S. S.; SHINGARE, M. S.; GILL*, C. H.; Bioorg.

The compounds (III) are screened in vitro for their antibacterial activity against E.