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Scholarly impact, as defined by academic productivity and scientific relevance, can be classified by the h-index and supplemented by the m and e-indices. This study has revealed well-defined differences in h, m, and e-indices with regard to academic rank among orthopaedic surgeons. Although the h, m, and e-indices may be of value as adjunct assessment devices for scholarly merit, careful consideration of their limitations must be maintained.

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Purpose: Gender disparities within academic promotion have been reported in several medical specialties. Female representation in association with research productivity has not been reported among academic dermatologists. As research productivity is a heavily weighted factor in determining promotion, we sought to determine whether gender disparities in academic rank and scholarly impact, measured by the h-index, exist in academic dermatology. Methods:In 2015, the authors determined gender and academic rank using academic dermatology department websites. Hindex and publication range were determined using the Scopus database. Rank, h-index, and publication range were compared between male and female academic dermatologists. Results:The h-index of academic dermatologists increased with successive academic rank from Assistant Professor through Professor (p<0.001), although no significant difference existed between Chairs and Professors. Publication range also increased with each successive rank from Assistant Professor through Professor (p<0.001), with no statistical significant difference between publication range of Chairs and Professors. Overall, men had higher h-indices than female colleagues (p<0.001). This difference was maintained when controlling for academic rank among Assistant Professors, Professors, and Chairs and when controlling for publication range in years. Conclusion:Women in academic dermatology are underrepresented among senior academic ranks. The difference in scholarly productivity between male and female academic dermatologists may contribute to this disparity. Recommendation for early involvement in research activities may help minimize this gap.

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An understanding of the molecular mechanisms of the newly characterized herpes simplex virus (HSV) B5 protein is important to further elucidate the HSV cell entry and infection. The synthetic peptide of B5 (wtB5) was functionalized with the nonlinear optical chromophore cascade yellow and its molecular dynamics was probed at physiological and endosomal pH (pH 7.4 and 5.5, respectively). Steady-state CD spectroscopy was utilized to characterize the peptides at different pH. These spectra showed structural changes in the peptide with time measured over several days. Nonlinear optical measurements were carried out to probe the interactions and local environment of the labeled peptide, and the increase in the two-photon cross section of this system suggests an increase in chromophore-peptide interactions. Time-resolved fluorescence upconversion measurements reflected changes in the hydrophilic and hydrophobic local environments of the labeled peptide-chromophore system. Ultrafast depolarization measurements gave rotational correlation times indicative of a reversible change in the size of the peptide. The time-resolved results provide compelling evidence of a reversible dissociation of the coiled coils of the wtB5 peptide. This process was found to be pH-insensitive. The data from this unique combination of techniques provide an initial step to understanding the molecular dynamics of B5 and a framework for the development of novel imaging methods based on two-photon emission, as well as new therapeutics for HSV.

Estimating variations in material properties over space and time is essential for the purposes of structural health monitoring (SHM), mandated inspection, and insurance of civil infrastructure. Properties such as compressive strength evolve over time and are reflective of the overall condition of the aging infrastructure. Concrete structures pose an additional challenge due to the inherent spatial variability of material properties over large length scales. In recent years, nondestructive approaches such as rebound hammer and ultrasonic velocity have been used to determine the in situ material properties of concrete with a focus on the compressive strength. However, these methods require personnel expertise, careful data collection, and high investment. This paper presents a novel approach using ground penetrating radar (GPR) to estimate the variability of in situ material properties over time and space for assessment of concrete bridges. The results show that attributes (or features) of the GPR data such as raw average amplitudes can be used to identify differences in compressive strength across the deck of a concrete bridge. Attributes such as instantaneous amplitudes and intensity of reflected waves are useful in predicting the material properties such as compressive strength, porosity, and density. For compressive strength, one alternative approach of the Maturity Index (MI) was used to estimate the present values and compare with GPR estimated values. The results show that GPR attributes could be successfully used for identifying spatial and temporal variation of concrete properties. Finally, discussions are presented regarding their suitability and limitations for field applications.