Background:The present study is an investigation of antiepileptic activity of Withania somnifera (Ashwagandha) is a well-known plant which is being used in tuberculosis, emaciation, sterility, and it has immunomodulatory, anabolic, anti-inflammatory, and antianxiety activities. Aims and Objectives: To find the efficacy of the alcoholic extract of W. somnifera (Dunal) in preventing experimentally-induced seizures. Materials and Methods: The alcoholic extract of W. somnifera was subjected to pilot study and then screened for anticonvulsant activity on maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures models in albino Wistar rats. Animals were treated with W. somnifera at doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg body weight and compared the results with control and standard. Results: Study results showed that W. somnifera extract at the dose of 300 mg/kg body weight when compared to control group highly significant (P < 0.01) reduction of hindlimb tonic extension and postictal depression in MES. PTZ-induced seizures showed significantly reduced mean duration of hindlimb tonic flexion, hindlimb tonic extension, clonus, and stupor and there was no postictal depression. Conclusions: The alcoholic extract of W. somnifera (Dunal) has shown a significant anticonvulsant effect at the dose of 300 mg/kg body weight, both in MES method and PTZ method and has given higher protection rate against pentylenetetrazol seizure than MES. KEY WORDS: Withania somnifera; Pentylenetetrazole; Maximal Electroshock ModelIndia has a rich treasure of medicinal plants and has contributed to the development of the well-known system of Ayurveda, the science of life. [5,6] Many medicinal plants from India have been shown to have activity by the traditional methods of psychoneuropharmacology. [7,8]

Objectives: To analyse the adverse drug reactions (ADRs) reported from clinical departments of a tertiary care hospital. Materials and Methods: A prospective, observational study to analyse the reported ADRs to the pharmacovigilance unit, Department of Pharmacology, East Point College of Medical Sciences and Research Centre, between 2019 and 2021. Institutional Ethics Committee approval was taken before doing the study. The data pertaining to various parameters were recorded in the Central Drugs Standard Control Organization (CDSCO) approved ADR reporting form and were analysed with respect to each reported data using descriptive statistics and expressed as numbers and percentages using Microsoft Excel. Results: Overall, 114 ADRs were reported during the study duration, and ADRs were most commonly reported amongst females (69) and 31–45 years (27.2%) age group. Causality assessment was done using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) scale, which showed 75 (66%) probable and 39 (34%) possible ADRs. The highest number of ADRs were reported by Medicine department (48.2%), emergency and intensive care unit (ICU) (16.6%) followed by Dermatology department (9.6%). The majority of them were due to antimicrobial agents (53.5%). The most commonly affected organ system was found to be dermatological (68.4%) followed by the body as a whole (15.7%) and gastrointestinal system (8.7%). The presentations of ADRs were diverse; itching and rashes (34 cases) were most commonly reported. Conclusion: This study gives an overall understanding of the current situation and trends in ADRs and their reporting status by health professionals in a tertiary care hospital, which would help to strengthen the pharmacovigilance activities at all levels of health care.