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The Internet of Things (IoT) is an extension of the traditional Internet, which allows a very large number of smart devices, such as home appliances, network cameras, sensors and controllers to connect to one another to share information and improve user experiences. Current IoT devices are typically micro-computers for domain-specific computations rather than traditional functionspecific embedded devices. Therefore, many existing attacks, targeted at traditional computers connected to the Internet, may also be directed at IoT devices. For example, DDoS attacks have become very common in IoT environments, as these environments currently lack basic security monitoring and protection mechanisms, as shown by the recent Mirai and Brickerbot IoT botnets. In this paper, we propose a novel light-weight approach for detecting DDos malware in IoT environments. We firstly extract one-channel gray-scale images converted from binaries, and then utilize a lightweight convolutional neural network for classifying IoT malware families. The experimental results show that the proposed system can achieve 94.0% accuracy for the classification of goodware and DDoS malware, and 81.8% accuracy for the classification of goodware and two main malware families. CCS CONCEPTS• Network security → IOT network security; • Machine learning → Convolutional neural network;

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FACILE is a language which symmetrically integrates concurrent and functional programming. It is a typed and statically scoped language. The language supports both function and process abstractions. Recursive functions may be defined and used within processes, and processes can be dynamically created during expression evaluation. Inter-process communication is by hand-shaking on typed channels. Typed channels, functions and process scripts are first-class values. In this paper, we present the "core" syntax of FACILE. We then describe an abstract machine C-FAM which executes concurrent processes evaluating functional style expressions. The operational definition of FACILE is presented by giving compilation rules from FACILE to C-FAM instructions, and execution rules for the abstract machine. An overview of the FACILE environment is also discussed.

Generation of RAS-targeted therapeutics has long been considered a "holy grail" in cancer research. However, a lack of binding pockets on the surface of RAS and its picomolar affinity for guanine nucleotides have made isolation of inhibitors particularly challenging. We recently described a monobody, termed NS1, that blocks RAS signaling and oncogenic transformation. NS1 binds to the α4-β6-α5 interface of H-RAS and K-RAS thus preventing RAS dimerization and nanoclustering, which in turn prevents RAS-stimulated dimerization and activation of RAF. Interestingly, NS1 reduces interaction of oncogenic K-RAS, but not H-RAS, with RAF and reduces K-RAS plasma membrane localization. Here, we show that these isoform specific effects of NS1 on RAS:RAF are due to the distinct hypervariable regions of RAS isoforms. NS1 inhibited wild type RAS function by reducing RAS GTP levels. These findings reveal that NS1 disrupts RAS signaling through a mechanism that is more complex than simply inhibiting RAS dimerization and nanoclustering.

Quantitative comparative evaluation provides details of exposure and surgical ease with both techniques. We promote hybrid/EDAC technique for vascular pathologies because of better anatomic orientation. Extradural clinoidectomy is the preferred technique for midline cranial neoplasia. An awareness of different variations of clinoidectomy can prevent dependency on any particular approach and facilitate flexibility.

For decades, the petrous part of the temporal bone has haunted skull base neurosurgeons and continues to do so. The depth of lesions, difficulties of approaches, and challenging neurovascular structures, e.g., brainstem and cranial nerves, have frightened neurosurgeons for decades, causing this area to have a reputation of a "No Man's Land." 17,18,22 Operative approaches to this area include clivectomy after transcervical, transoral, extended transoral, subfrontal, transsellar-transcavernous, transsylvian, combined transsylvian and anterior subtemporal, and combined transsylvian and transpetrosal approaches. Approaches vary from pure extradural to intradural and combined ones. obJect The surgical corridor to the upper third of the clivus and ventral brainstem is hindered by critical neurovascular structures, such as the cavernous sinus, petrous apex, and tentorium. The traditional Kawase approach provides a 10 × 5-mm fenestration at the petrous apex of the temporal bone between the 5th cranial nerve and internal auditory canal. Due to interindividual variability, sometimes this area proves to be insufficient as a corridor to the posterior cranial fossa. The authors describe a modification to the technique of the extradural anterior petrosectomy consisting of additional transcavernous exploration and medial mobilization of the cisternal component of the trigeminal nerve. This approach is termed the modified Dolenc-Kawase (MDK) approach. methods The authors describe a volumetric analysis of temporal bones with 3D laser scanning of dry and drilled bones for respective triangles and rhomboid areas, and they compare the difference of exposure with traditional versus modified approaches on cadaver dissection. Twelve dry temporal bones were laser scanned, and mesh-based volumetric analysis was done followed by drilling of the Kawase triangle and MDK rhomboid. Five cadaveric heads were drilled on alternate sides with both approaches for evaluation of the area exposed, surgical freedom, and angle of approach. results The MDK approach provides an approximately 1.5 times larger area and 2.0 times greater volume of bone at the anterior petrous apex compared with the Kawase's approach. Cadaver dissection objectified the technical feasibility of the MDK approach, providing nearly 1.5-2 times larger fenestration with improved view and angulation to the posterior cranial fossa. Practical application in 6 patients with different lesions proves clinical applicability of the MDK approach. coNclusioNs The larger fenestration at the petrous apex achieved with the MDK approach provides greater surgical freedom at the Dorello canal, gasserian ganglion, and prepontine area and better anteroposterior angulation than the traditional Kawase approach. Additional anterior clinoidectomy and transcavernous exposure helps in dealing with basilar artery aneurysms.

Background. Family clusters and epidemics of toxoplasmosis in North, Central, and South America led us to determine whether fathers of congenitally infected infants in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) have a high incidence of Toxoplasma gondii infection.Methods. We analyzed serum samples collected from NCCCTS families between 1981 and 2013. Paternal serum samples were tested for T. gondii antibodies with immunoglobulin (Ig) G dye test and IgM enzyme-linked immunosorbent assay. Additional testing of paternal serum samples was performed with differential-agglutination and IgG avidity tests when T. gondii IgG and IgM results were positive and serum samples were collected by the 1-year visit of the congenitally infected child. Prevalence of paternal seropositivity and incidence of recent infection were calculated. We analyzed whether certain demographics, maternal parasite serotype, risk factors, or maternal/ infant clinical manifestations were associated with paternal T. gondii infection status.Results. Serologic testing revealed a high prevalence (29 of 81; 36%) of T. gondii infection in fathers, relative to the average seropositivity rate of 9.8% for boys and men aged 12-49 years in the United States between 1994 and 2004 (P < .001). Moreover, there was a higher-than-expected incidence of recent infections among fathers with serum samples collected by the 1-year visit of their child (6 of 45; 13%; P < .001). No demographic patterns or clinical manifestations in mothers or infants were associated with paternal infections, except for sandbox exposure.Conclusions. The high prevalence of chronic and incidence of recent T. gondii infections in fathers of congenitally infected children indicates that T. gondii infections cluster within families in North America. When a recently infected person is identified, family clustering and community risk factors should be investigated for appropriate clinical management.