Cefuroxime axetil is a broad-spectrum antibiotic with a simple pharmacokinetic profile. The medicine treats otitis media, pharyngitis, sinusitis, CAP, and acute exacerbations of chronic bronchitis effectively and well. Cefuroxime axetil was beneficial in intravenous/oral sequential therapy for CAP, but dosage recommendations are not accessible in some countries. Cefuroxime axetil may be used to treat community-acquired infections, including those caused by -lactamase-producing respiratory bacteria. In an era of rapidly growing bacterial resistance, empirical treatment with cefuroxime axetil may assure the proper use of newer antibacterial medicines, reducing bacterial resistance to these drugs.
Modern medicines for human use are required to comply with specific standards and regulation set forth by the concerned authorities. A simple and sensitive UV spectrophotometric method was developed and validated for the simultaneous determination of Potassium Clavulanate (PC) and Amoxicillin. As complementary of this work, an assay method for amoxicillin and potassium clavulanate mixtures was developed and validated; stress-testing and stability studies of amox/clav mixtures was carried out under specified conditions according to ICH and analyzed by using validated stability-indicating assay and related substances methods. Aim of this study was to test the validation of derivative spectrophotometric method in simultaneous determination the content amoxicillin and clavulanate potassium in dry syrup by derivative spectrophotometric method with zero crossing technique, in buffer phosphate pH 4,4-methanol (91:9) mixture.
The bioanalytical analysis of anticancer agents established a more personalized treatment procedure. The importance of validating analytical procedures before they are put into normal usage is widely acknowledged. This novel approach has a lot of promise because it is quick, easy, and only requires a little amount of samples to get the accurate result. The goal of this mini review is to provide a comparative analysis of contemporary research on few anticancer agents and their methodology in reference to bioanalytical analysis. We provide practical approaches for determining extraction and clean up, precision and accuracy, selectivity and specificity, chromatographic analysis and its validation. We believe that the liquid chromatographic processes used in the bioanalysis of anticancer medicines, validation standards might have been applied in a variety of ways to counter the failure of an anticancer agent by increasing its therapeutic index approach.
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