BackgroundTuberculosis (TB) infection induces profound local and systemic, immunological and inflammatory changes that could influence the development of other respiratory diseases; however, the association between TB and asthma is only partly understood. Our objective was to study the association of TB with asthma and respiratory symptoms in a Nordic–Baltic population-based study.MethodsWe included data from the Respiratory Health in Northern Europe (RHINE) study, in which information on general characteristics, TB infection, asthma and asthma-like symptoms were collected using standardised postal questionnaires. Asthma was defined based on asthma medication usage and/or asthma attacks 12 months prior to the study, and/or by a report of ≥three out of five respiratory symptoms in the last 12 months. Allergic/nonallergic asthma were defined as asthma with/without nasal allergy. The associations of TB with asthma outcomes were analysed using logistic regressions with adjustments for age, sex, smoking, body mass index and parental education.ResultsWe included 8379 study participants aged 50–75 years, 61 of whom reported having had TB. In adjusted analyses, participants with a history of TB had higher odds of asthma (OR 1.99, 95% CI 1.13–3.47). The associations were consistent for nonallergic asthma (OR 2.17, 95% CI 1.16–4.07), but not for allergic asthma (OR 1.20, 95% CI 0.53–2.71).ConclusionWe found that in a large Northern European population-based cohort, persons with a history of TB infection more frequently had asthma and asthma symptoms. We speculate that this may reflect long-term effects of TB, including direct damage to the airways and lungs, as well as inflammatory responses.
BackgroundGiven the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring.ObjectiveThis study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms.MethodsWe included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma.ResultsOf 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05–1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29–2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76–1.32) in offspring was observed.ConclusionResults from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.
Spot blotch disease (SB) caused by Bipolaris sorokiniana (teleomorph:Cochliobolus sativus) is a major disease of barley and causes a significant yield loss under favorable conditions in the warm and humid areas. A global set of 340 barley germplasm obtained from ICARDA were evaluated for SB resistance under natural epiphytotic conditions along with two local checks (Bonus and Solu Uwa) at the research field of Nepal Agricultural Research Council, Rampur, Chitawan, Nepal for three consecutive years (2016)(2017)(2018). Analysis of variance showed significant variation in Area Under Disease Progress Curve (AUDPC) of the studied genotypes in all the three years' experiments. The check varieties were susceptible to SB (AUDPC value ≥ 750) in all the experiments. In the first-year experiment, 28, 105, 98 and 109 genotypes had resistant (R, AUDPC <250), moderately resistant (MR, AUDPC 250-499), moderately susceptible (MS, AUDPC 500-749), and susceptible (S, AUDPC≥750) type of disease reaction, respectively. In the second year, 1, 42, 136 and 161 genotypes showed R, MR, MS, and S type of disease reaction. In the third-year, 69 genotypes had MR, 132 MS and 139 S type of disease reaction. Summarized across the years, about 27 % genotypes had MS to MR or R type of SB reaction. The study identified barley lines that can be a potential source of SB resistance for barley breeding programs.
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