Background: In both economically developing and non-developing countries, hypertension is a major public health issue. India has been reported to have lower hypertension prevalence rates. The blood pressure of city dwellers is higher than that of rural dwellers. India is a populous and typical developing country with a vast population. Renal failure is defined as the retention of nitrogenous waste products due to impairment of renal function. Acute renal failure and chronic renal failure are the two types of renal failure. Acute renal failure is described as kidney failure that occurs in a matter of days or weeks. Acute renal failure is most common in older persons and is linked with considerable mortality and morbidity, with death rates ranging from 25 to more than 70% among hospitalized patients. Aim: To establish the above biochemical parameters for diagnosis and management of hypertension and renal failure. Material and Method: The clinical materials for present study entitled “To Study the Biochemical Parameter in Hypertension and Renal Failure” comprised 52 male hypertensive patients. 39 female hypertensive patients, 50 male chronic renal failure patients, 43 female chronic renal failure patients, 42 male chronic renal failure with hypertension, 40 female chronic renal failure with hypertension, 36 male acute renal failure, 48 female acute renal failure were admitted in Hospital. Results: Results revealed that highly significant decreased level of protein (Total), creatinine, and P-MDA were observed respectively. Serum sodium was found to be significant. Significant increased potassium was observed. Highly significant level of glucose, glutathione reductase, glutathione peroxidase, and catalase were observed respectively. Focus on acute renal failure patients were analyzed in both male and female. Highly significant decreased level of protein (Total), superoxide dismutase and P-MDA were observed respectively, glutathione reductase, glutathione peroxidase, and catalase were observed respectively. Significant increased serum glucose was observed, and highly significant increased level of glutathione reductase, glutathione peroxidase, and catalase were observed respectively. Conclusion: The study's key finding is that oxidative stress causes hypertension and can signal the onset of chronic renal failure. Oxidative stress in older people became more severe, especially if they had renal difficulties, especially in middle age. Keywords: P-MDA, Glutathione reductase, glutathione peroxidase, SOD, DBP
Background: Iodine (I) is a trace element that is required by both humans and animals. It can be found in a variety of chemical forms, including iodine, iodide (I), and iodate (IO3). It is widely distributed across the earth's ecology, with a concentration in the oceans. Iodine entered the natural cycle from the ocean, the atmosphere, and rainfall, as well as from rainfall into streams and rivers. Iodine is absorbed as iodide in human nutrition. Iodine is a necessary micronutrient and a component of thyroid hormones. Fish and seafood have a high iodine level. The amount of iodine in soil and drinking water varies depending on where it comes from. Iodine shortage produces a variety of negative health consequences, which are referred to as iodine deficiency illnesses (IDD). These conditions are caused by a lack of iodine, which causes insufficient thyroid hormone production. Aim: The aim of this study is to characterize the iodine deficiency disorder by biochemical and clinical assessment and to correlate the iodine status with thyroid disorder(s) in adults. Material and Method: The samples for this investigation were taken from patients at the Department of Endocrine Surgery. This study comprised a total of 100 hundred goiter patients, who had their urinary iodine excretion and thyroid hormone levels examined. For all goiter patients, the grading of goitre was established using the WHO/UNICEF/ICCIDD approved criteria. TSH, Free T4, Free T3 by using ELISA Method using commercial kits. Anti-microsomal antibody (AMA) or Thyroperoxidase antibody (TPO-Ab) by using ELISA Method using commercial kits. Anti-thyroglobulin antibody (ATG) estimated by using ELISA Method using commercial kits. Results: The data for each group were presented as Median and inter quarter range (IQR) The median and IQR of Urinary iodine excretion of the hypothyroid, hyperthyroid and Euthyroid goiter subjects were respectively and there was significant difference in the median urinary iodine excretion. The median and IQR of Urinary iodine excretion of the thyroiditis, thyrotoxicosis, cancer of thyroid and benign goiter respectively and there was significant difference in the median urinary iodine excretion. Conclusion: For ages, endemic goitre and cretinism have been recognised as public health issues, and iodine deficiency is thought to be the leading cause of preventable mental retardation. Most countries now include iodine deficiency control as part of their national nutrition policies. To eliminate iodine deficiency, several therapies with high efficacy have been employed, including iodized oil capsules (IOC) and universal salt iodisation (USI). Although some progress has been made, efforts to eliminate this devastating health problem must be hastened. Not only should iodine deficiency be monitored, but so should excessive iodine intake, as this is a problem in various areas, including the camps. Keywords: IDD, Goitre, TSH, IOC, USI, ATG, AMA, T4, T3.
Background: Tissue inflammation, low food intake of micronutrients due to sleepiness, free radical burst from activated macrophages, and excessive medication cause oxidative stress in acute poisoning. If not neutralised by antioxidants, these free radicals may contribute to tissue inflammation. The word oxidative stress refers to a scenario in which free radical generation and antioxidant defence are out of balance. In humans, oxidative stress is caused by a reduction in bodily antioxidants when free radical generation exceeds endogenous antioxidant levels, resulting in significant cell damage/death. Free radicals may destroy all major macromolecules, including lipids, proteins, and nucleic acids, but lipids are the most vulnerable. Aim: To evaluate antioxidant status in acute amitriptyline poisoning (AP) cases undergoing routine standard treatment (RST) after supplementation with Vitamin C and alpha lipoic acid either alone or in combination, and compare it with that of normal healthy volunteers. Material and Method: A total of 150 people were enrolled in the study, and they were split into five groups. They came from the IMCU and the Toxicology Ward. The consent of the patients' attendants was sought. The patients were chosen at random. To classify the level or grade of coma in poisoned individuals, the Edinburgh scale was utilized. At the time of admission and discharge, the levels of plasma cholinesterase, SOD, catalase, Glut-peroxidase, Glutathione transferase, MDA, Total-Antioxidant, LDH, and CK were measured. Results: This study offers quantifiable recommendations for vitamin C and alpha lipoic acid intake to aid in rapid recovery and glutathione antioxidant status. On supplementation with vitamin C and alpha lipoic acid, we detected a significant decrease in catalase activity in all groups of acute Amitriptyline poisoning cases. For Gr. V (acute Amitriptyline poisoning cases), we found reduced glutathione activity on admission and higher values on discharge. In light of the preceding discussion, it is worth noting that the higher LDH and CPK in groups that may be attributable to pulmonary infarction rather than cardiac or skeletal muscle involvement could be due to pulmonary infarction. Conclusion: Supplementation with vitamin C and alpha lipoic acid improved antioxidant levels during therapy. We propose that the antioxidant level of acute amitriptyline poisoning cases be examined for more successful recovery, and that diets poor in antioxidants may cause recovery to be sluggish. Oral supplementation, in our opinion, will be more successful for chronic Amitriptyline poisoning patients for a longer period of time, while IV form of vitamin C and alpha lipoic acid will be more effective for acute Amitriptyline poisoning instances. Keywords: Amitriptyline, MDA, Total-Antioxidant, LDH, CK, SOD, AP, RST.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.