According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.
Debugging on computer program is a complex cognitive activity. Although it is complex, it's still one of the popular issues in computer programming task. It is a difficult task, which is to understand what the error is and how to solve such error? In computer programming the difficulty is to understand the Object-Oriented programming concept together with the programming logic. If the programming logic is incorrect, the program codes will have such error named as logic error and can caused highly maintenance cost. Logic error is a bug in a program that causes it to operate incorrectly, without terminating or crashing the program. It will produce unintended output or other behavior than what we are expecting. Method that use to develop a propose model Object Oriented Debugger is Unified Modeling Language (UML). It is the best choice model and suitable to design the Object Oriented Debugger which will be developed in an object oriented programming environment. The model will provide an ability to capture the characteristics of a system by using notations in the process of designing and implementing the system. The model of Object Oriented Debugger has been successfully implemented. This model has been developed using Unified Approach methodology, which consists of two methods such as Object-Oriented Analysis (OOA) and Object-Oriented Design (OOD). The model developed is to capture the structure and behavior of the Object Oriented Debugger by using the UML diagram. The model also can ease the readability of the documentation for the maintenance purposes. The design of the Object Oriented Debugger Model has been developed using the UML notation. It's consisting of two parts that are object-oriented analysis and object-oriented design. All the developing and designing are based on the model in UML.
Nitrogen is the most limiting major nutrient required by all living plants. Nitrogen fertilizer is costly and too much application of nitrogen causes detrimental effects to our ecosystem. Alternatively, the use of commercial microbial inoculants will be an alternative to chemical fertilizer for the small holder farmers in northern Nigeria. Groundnut (pea nut) was selected as a test crop for the inoculation. The experiment was conducted at Sudan savannah in Kano State and Guinea savannah in Bauchi state of Nigeria during the 2016 cropping season. The design of the experiment was RCBD with seven treatments and four replications in each site. Two rhizobia inoculants were tested on groundnut in two agroecological zones of northern Nigeria to monitor their performance and their ability to establish symbiotic and nodulate the crops. The treatments combinations were; histic, biofix, nitrogen, cattle manure, histic + cattle manure, biofix + cattle manure and control. In the groundnut field, Biofix produced higher nitrogen fixed than all treatments in the Sudan savanna, while in the Guinea savanna no significant differences (P = 0.67) were observed between the treatments and the control. However, inoculated plots had higher nitrogen fixation than the control.
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