1-Nitroisoquinolines were directly prepared from the corresponding isoquinolines with potassium nitrite and acetic anhydride in DMSO in good yields.Nucleophilic substition in the heterocyclic ring of isoquinoline 1 normally requires attack by a powerful nucleophile. In practice, amide and hydroxide ions have been employed for the nucleophilic substitution of isoquinoline at the C-1 position. 'From calculation^,^^^ C-1 is proven to have the lowest 7c-Paper 6/03 159E
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.