<b><i>Introduction:</i></b> Individualized homeopathy (IH) in atopic dermatitis (AD) remained under-researched. <b><i>Objective:</i></b> We aimed at evaluating efficacy of IH in AD. <b><i>Methods:</i></b> A double-blind, randomized, placebo-controlled, short-term, preliminary trial was conducted in an Indian homeopathy hospital. Patients were randomized to either IH (<i>n</i> = 30) or identical-looking placebo (<i>n</i> = 30) using computerized randomization and allocation. Outcomes were patient-oriented scoring of AD (PO-SCORAD; primary end point), Dermatological Life Quality Index (DLQI) score, and AD burden score for adults (ADBSA; secondary end points), measured monthly for 3 months. An intention-to-treat sample was analyzed after adjusting baseline differences. <b><i>Results:</i></b> On PO-SCORAD, improvement was higher in IH against placebo, but nonsignificant statistically (<i>p</i><sub>month 1</sub> = 0.433, <i>p</i><sub>month 2</sub> = 0.442, <i>p</i><sub>month 3</sub> = 0.229). Secondary outcomes were also nonsignificant – both DLQI and ADBSA (<i>p</i> > 0.05). Four adverse events (diarrhea, injury, common cold) were recorded. <b><i>Conclusions:</i></b> There was a small, but nonsignificant direction of effect towards homeopathy, which renders the trial inconclusive. A properly powered robust trial is indicated.
Amberlite resin formate (ARF) with a polyionic polar environment is successfully utilized as a unique support for immobilization of stabilized Cu 2 O nanoparticles (NPs). The composite [Cu 2 O@ARF] is characterized by FT−IR, XRD, XPS, HR−TEM, and ICP−AES analyses. The HR−TEM results confirm existence of fairly dispersed Cu 2 O NPs with average diameter (∼5−7 nm) onto the resin surface, while ICP−AES analyses show loading of copper (10.8 mg) per gram of the resin composite (1.08 wt % of Cu). The ionic resin with counteranions (HCOO − ) could reduce precursor Cu(II) to Cu(I) and stabilize Cu 2 ONPs. The as-synthesized composite acts as a robust, efficient, and recyclable catalyst for efficient construction of a 1,2,3-triazole ring under aqueous and aerobic conditions. The TOF (219 h −1 ) is found significantly high as compared to that of some related existing catalysts (120 h −1 ). The prowess of the catalyst is further demonstrated in the synthesis of a triazole-bearing antitumor drug molecule.
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