In the era of increasing demand for indigenous medicines, maintaining quality standards is the need of the hour. Standardisation of compound formulations is lagging behind because of absence of reference standards. Manjishthadi Ghanavati is an important Ayurvedic formulation containing Manjishtha (Rubia cordifolia Linn.), Haritaki (Terminalia chebula Retz.), Amalaki (Emblica officinalis Gaertn.), Bibhitaki (Terminalia bellerica Roxb.), Katuki (Picrohriza kurroa Royle. ex Benth), Vacha (Acorus calamus Linn.), Daruharidra (Barberis aristata DC) Guduchi (Tinospora cordifolia Willd.) and Nimba (Azadirechta indica A Juss.). All the constituents are available and prepared according to the reference present in Sharangadhara Samhita Madhyama Khanda Chapter 2/136. Hence the present study was undertaken to standardize the compound Ayurvedic formulation through Pharmacognostical and pharmaceutical evaluation. The sample was subjected for various phytochemical parameters like water soluble extractive (49.72%w/w), alcohol soluble extractive (41.28 % w/w), ash value (10 % w/w), loss on drying (10.85 % w/w), the pH (6.0), Hardness(4 kg/cm 2) and Disintegration time (32 min.). The HPTLC, solvent system was Toluene: ethyl acetate (9:1), showed the presence of 7 spots at 254nm and 2 spots at 366nm. Thus, the physiochemical and microscopic characters achieved may provide guidelines for standardization of formulation Manjishthadi Ghanavati.
Background: Acne vulgaris is a chronic inflammatory condition of skin in youth. In Ayurveda, acne has been elaborated as one of the Kshudra Rogas. In this modern era, this is a burning problem in the adolescence. Symptoms of Mukhadushika show close resemblance with bacterial infection and inflammatory factors of acne. In Ayurveda, it can be correlated with Mukhadushika. Vitiation of Kapha Dosha, Vata Dosha and Rakta Dhatu lead to development of Mukhadushika. Methods: A 25-year-old patient presented with complaint of Pidaka (Papules and putules) on face and neck including Medogarbhatva (filling material), Todavat peeda (Piercing pain), Daha (Burning sensation), Srava (Discharge) and Kandu (itching) associated with irregular bowel and recurrent comedones, since 1 year. Management done with OPD based treatment. Here in this case report treatment chosen was i.e. Avipattikar churna orally and Lodhradi lepa for external application along with Baspa Sweda (take a steam) for 1 month followed by Kumkumadi Taila for next 15 days. Result: There was marked improvement in symptoms Pidaka (Papules and pustules) on face and neck including Medogarbhatva (filling material or nodules), Todavat peeda (Piercing pain), Daha (Burning sensation), Srava (Discharge) and Kandu (itching) associated with irregular bowel and recurrent comedone with the treatment of 1.5 month. Conclusion: Significant result was observed with this treatment protocol in the management of Mukhadushika (Acne vulgaris).
Background: Durvadi Ghrita is a Sneha Kalpana which is claimed to be effective in Madhumehajanya Timira (Diabetic Retinopathy). In present study, it has been used for Nasya. Objective: Present study was planned to look out on herbal drugs used in the preparation of Durvadi Ghrita and standardization of drug by pharmacognostical and physicochemical parameters and HPTLC evaluation. Methods: Identification and authentication of all the raw drug was done by pharmacognostical study i.e. morphological characters, organoleptic characters and powder microscopy. Physicochemical evaluation and HPTLC of final product were done. Results: Pharmacognostical study of all the raw drugs of Durvadi Ghrita showed presence of oil globule, prismatic crystals of Durva. Lignified branched trichome, pollen grains of Utpala Kinjalaka. Trichome, border pitted vessels of Manjishtha. Collenchyma cells, border pitted vessel of Elvaluka. Lignified fibres, oil globules of Sita. Pitted fibres, pitted vessels of Usheera. Scalariform vessels, prismatic crystals of Musta. Pitted vessels and lignified fibres, crystal fibres of Chandana. Lignified cork, and stone cells of Padmaka etc. Pharmaceutical evaluation of Durvadi Ghrita showed results Specific Gravity 0.9125, Refractive Index 1.47, Acid Value 0.4608, Iodine Value 11.45 and Saponification Value 128.856. High Performance Thin Layer Chromatography, 12 spots were found at 254 nm and five spots were found at 366 nm. Conclusion: Identification and authentication of herbal drug used in the preparation of Durvadi Ghrita has been done. Pharmacognostical and physicochemical evaluation of prepared drug has been carried out which can be further useful for standardization of Durvadi Ghrita and other clinical researches.
Pilla Shukra Nashaka Anjana Varti is an important Ayurvedic formulation containing Haritaki (Terminalia chebula Retz.), Amalaki (Emblica officinalis Gaertn.), Bibhitaki (Terminalia bellerica Roxb.), Katuki (Picrohriza kurroa Royle. ex Benth), Pippali (Piper longum Linn.), Saindhava (Sodium chloridum), Shankhabhasma and Tamra Bhasma. All the constituents are available and prepared according to the reference present in Ashtanga Hridaya Uttaratantra. No any work has been carried out for standardization of Pilla Shukra Nashaka Anjana Varti till date. For standardization of this Ayurvedic drug through Pharmacognostical and pharmaceutical evaluation, the present study was done. The sample was given for different phytochemical characters like ash value (34.33%w/w), alcohol soluble extract (55.62% w/w), water soluble extract (45.30% w/w), loss on drying (6.8%w/w), pH (6.5) and HPTLC. The HPTLC, solvent system was Toluene:ethyl acetate (9:1), showed the presence of 8 spots at 254nm and 4 spots at 366nm. Hence physiochemical and microscopic parameter achieved may gives guidelines for standardization of drug, Pilla Shukra Nashaka Anjana Varti.
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