patients is important which might improve outcomes. Also, the rate of distant metastasis in patients with T4b disease was 19% and among those with T4a disease was 11%. Table: 341O 3 -year DFS T4a T4b Chemo-radiation(with ECS & margin positivity) 41.6% 33.6% Radiation alone 72.2% 42.1% p-value 0.000 0.074 Conclusions: T4b is more aggressive disease than T4a.Treatment intensification with the addition of chemotherapy to radiation may benefit select patients with T4b buccal mucosa cancers and might help in reducing the rate of distant metastasis. Legal entity responsible for the study: Manish Mair Funding: None Disclosure: All authors have declared no conflicts of interest. 342P QOL analysis of a phase II randomized controlled clinical trial comparing efficacy of cabazitaxel versus docetaxel as second line or above therapy in recurrent head and neck cancer
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