Polycyclic aromatic hydrocarbons (PAHs) are promising for materials science because of their high thermal and chemical stability, electron mobility, and unique photophysical properties. However, flat PAHs have limited applications owing...
An efficient and straightforward
approach to allylaluminum reagent
synthesis through Cu-catalyzed hydroalumination of readily accessible
allenes with diisobutylaluminum hydride is described. The N-heterocyclic
carbene-based copper complex promotes hydride addition to various
functionalized allenes under mild reaction conditions. The catalytic
reaction is applied to a highly selective one-pot synthesis of allylic
ketones with α-tertiary and α-quaternary centers through
tandem nucleophilic addition of in situ-generated allylaluminums to
aldehydes/Oppenauer oxidation.
One‐pot synthesis of 2‐aminobenzoxazoles through copper‐catalyzed electrophilic amination of benzoxazoles with O‐benzoyl hydroxylamines is described. The direct magnesation of benzoxazoles with the readily available iPrMgCl generated benzoxazolylmagnesium reagents in situ and these reagents were treated with electrophilic amines in the presence of 10 mol‐% Cu(OAc)2 and ZnCl2 under mild reaction conditions. A variety of 2‐aminobenzoxazoles were obtained in good to excellent yields.
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