No abstract

The discrete specmm of the hydrogen atom moving acmss a stmng magnetic field (E = 7 x 10"-7 x IO'* G) is studied by expanding wavefunctions over a complete onhogonal basis, whose single term pmvides a correct description of an mmic state at large pseudomomenta K of the h'ansverse motion. Wavefunctions, energies, atomic sires and oscillator strengths of radiative transitions a~ calculated and analysed in a wide range of K values. AU these quantities undergo radical changes when the atom moves acioss the field. The discrete s p e c " remains infinite at arbitrary K. although the mean transverse velocity cannot exceed some maximum value for lhe bound states. Oscillator e n g t h s change by orders of magnitude and some dipole selection rules are violated.

Objective To evaluate previously reported associations of copy number variants (CNVs) with schizophrenia and to identify additional associations, the authors analyzed CNVs in the Molecular Genetics of Schizophrenia study (MGS) and additional available data. Method After quality control, MGS data for 3,945 subjects with schizophrenia or schizoaffective disorder and 3,611 screened comparison subjects were available for analysis of rare CNVs (<1% frequency). CNV detection thresholds were chosen that maximized concordance in 151 duplicate assays. Pointwise and gene-wise analyses were carried out, as well as analyses of previously reported regions. Selected regions were visually inspected and confirmed with quantitative polymerase chain reaction. Results In analyses of MGS data combined with other available data sets, odds ratios of 7.5 or greater were observed for previously reported deletions in chromosomes 1q21.1, 15q13.3, and 22q11.21, duplications in 16p11.2, and exon-disrupting deletions in NRXN1. The most consistently supported candidate associations across data sets included a 1.6-Mb deletion in chromosome 3q29 (21 genes, TFRC to BDH1) that was previously described in a mild-moderate mental retardation syndrome, exonic duplications in the gene for vasoactive intestinal peptide receptor 2 (VIPR2), and exonic duplications in C16orf72. The case subjects had a modestly higher genome-wide number of gene-containing deletions (>100 kb and >1 Mb) but not duplications. Conclusions The data strongly confirm the association of schizophrenia with 1q21.1, 15q13.3, and 22q11.21 deletions, 16p11.2 duplications, and exonic NRXN1 deletions. These CNVs, as well as 3q29 deletions, are also associated with mental retardation, autism spectrum disorders, and epilepsy. Additional candidate genes and regions, including VIPR2, were identified. Study of the mechanisms underlying these associations should shed light on the pathophysiology of schizophrenia.

Recent results from BOOMERANG-98 and MAXIMA-1, taken together with COBE DMR, provide consistent and high signal-to-noise measurements of the cosmic microwave background power spectrum at spherical harmonic multipole bands over 2

We set new constraints on a seven-dimensional space of cosmological parameters within the class of inflationary adiabatic models. We use the angular power spectrum of the cosmic microwave background measured over a wide range of in the first flight of the MAXIMA balloon-borne experiment (MAXIMA-1) and the low results from COBE/DMR. We find constraints on the total energy density of the universe, Ω = 1.0 +0.15 −0.30 , the physical density of baryons, Ω b h 2 = 0.03 ± 0.01, the physical density of cold dark matter, Ω cdm h 2 = 0.2 +0.2 −0.1 , and the spectral index of primordial scalar fluctuations, n s = 1.08 ± 0.1, all at the 95% confidence level. By combining our results with measurements of high-redshift supernovae we constrain the value of the cosmological constant and the fractional amount of pressureless matter in the universe to 0.45 < Ω Λ < 0.75 and 0.25 < Ω m < 0.50, at the 95% confidence level. Our results are consistent with a flat universe and the shape parameter deduced from large scale structure, and in marginal agreement with the baryon density from big bang nucleosynthesis. Subject headings: cosmic microwave background-cosmology: observations-large-scale structure of universe