Abstract. In data grid, large quantity of data files is produced and data replication is applied to reduce data access time. Efficiently utilizing grid resources becomes important research issue since available resources in grid are limited while large number of workloads and large size of data files are produced. Dynamic replication in data grid aims to reduce data access time and to utilize network and storage resources efficiently. This paper proposes a novel dynamic replication strategy, called BHR, which reduces data access time by avoiding network congestions in a data grid network. With BHR strategy, we can take benefits from 'network-level locality' which represents that required file is located in the site which has broad bandwidth to the site of job execution. We evaluate BHR strategy by implementing it in an OptorSim, a data grid simulator initially developed by European Data Grid Projects. The simulation results show that BHR strategy can outperform other optimization techniques in terms of data access time when hierarchy of bandwidth appears in Internet. BHR extends current site-level replica optimization study to the network-level.
In this paper, we discuss on the extension of grid computing systems in mobile computing environments, where mobile devices can be effectively incorporated into the grid either as service recipients or as more valuable service providers. First, based on the present grid architecture, we try to figure out what would be the newly required services in such a mobile/grid integrated architecture. There are a number of challenging issues when taking mobile environment into account, such as intermittent connectivity, device heterogeneity, and weak security. Among these issues to solve, we particularly focus on a disconnected operation problem in this paper since mobile resources are prone to frequent disconnections due to their confined communication range and device mobility. We develop a new job scheduling algorithm for mobile grid system and evaluate it by various methods such as mathematical analysis, simulation, and prototype implementation.
BACKGROUND Antihypertensive therapy using renin–angiotensin system blockers and calcium channel blockers to target blood pressure variability (BPV) has not yet been established. We aimed to compare the ability of losartan and amlodipine to lower BPV and systolic blood pressure (SBP) in essential hypertensive patients. METHODS Patients were randomly assigned either losartan 50 mg or amlodipine 5 mg. Medications were uptitrated and hydrochlorothiazide was added according to protocol for 6 months. The primary endpoint was the office visit-to-visit SD of SBP. The secondary endpoints included average real variability (ARV), office SBP, and home SBP. RESULTS The losartan group (n = 71) and amlodipine group (n = 73) finished the scheduled visits between April 2013 and May 2017. The office visit-to-visit SD of SBP was comparable between the losartan and amlodipine groups (11.0 ± 4.2 vs. 10.5 ± 3.8, P = 0.468). The office visit-to-visit ARV of SBP was significantly elevated in the losartan group (10.6 ± 4.3 vs. 9.1 ± 3.4, P = 0.02). The absolute SBP decrement from baseline to 6 months was similar between groups, although the office mean SBP at 6 months was higher in the losartan group (132.3 ± 12.9 vs. 127.5 ± 9.0 mm Hg, P = 0.011). In home blood pressure analysis, evening day-to-day BPV indexes (SD and ARV) were significantly higher in the losartan group at 6 months. CONCLUSIONS The lowering effect of the office visit-to-visit SD of SBP was similar between losartan and amlodipine. However, the losartan group showed a higher office visit-to-visit ARV of SBP and evening day-to-day home BPV indexes. Therefore, amlodipine may be better to lower BPV in essential hypertensive patients.
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