The measurement of urinary iodine in population-based surveys provides a biological indicator of the severity of iodine-deficiency disorders. We describe the steps performed to validate a simple, inexpensive, manual urinary iodine acid digestion method, and compare the results using this method with those of other urinary iodine methods. Initially, basic performance characteristics were evaluated: the average recovery of added iodine was 100.4 +/- 8.7% (mean +/- SD), within-assay precision (CV) over the assay range 0-0.95 mumol/L (0-12 micrograms/dL) was < 6%, between-assay precision over the same range was < 12%, and assay sensitivity was 0.05 mumol/L (0.6 microgram/dL). There were no apparent effects on the method by thiocyanate, a known interfering substance. In a comparison with five other methods performed in four different laboratories, samples were collected to test the method performance over a wide range of urinary iodine values (0.04-3.7 mumol/L, or 0.5-47 micrograms/dL). There was a high correlation between all methods and the interpretation of the results was consistent. We conclude that the simple, manual acid digestion method is suitable for urinary iodine analysis.
with the collaboration of Sandy May and Glen Maberly Editorial comment During the 13 years after iodized salt was introduced into Guatemala in 1952, the prevalence of goitre fell from 39% to 5%, and for many years thereafter it was difficult to find examples of endemic goitre to demonstrate to students on field visits. However, with the political turmoil of the 1980s, the iodization of salt in Guatemala lapsed and goitre returned. An effort is being made to restore an effective iodization programme. The results are still highly unsatisfactory, as the following article reports. If the problem were specific to Guatemala, this article would not have been accepted for publication. Unfortunately, it serves as a reminder of a situation that prevails in many developing countries today even when their salt or part of it is stated to be iodized. Government regulatory authorities and United Nations institutions should be alerted by this article to carry out similar evaluations in their own countries on a continuing basis.
Marginalia is the practice of writing notes in the margins of texts as a way to capture ones’ thoughts and feelings about the text during reading. It is the giving in to the impulse, based on what was read, to stop and record a comment. In this manuscript, we make the connection between marginalia and the visceral responses to text felt by one doctoral student (the second author) taking a course examining language as a “place of struggle” (hooks, 2004, p. 153). We also demonstrate how marginalia can be used as a qualitative method to document and investigate the way textual interaction facilitates learning. A found poem developed from the marginalia compiled throughout the semester is shared exemplifying the way a critical analysis of personal marginalia can facilitate awareness of transformative processes and highlighting the margins as a transformative space.
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