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Croton heliotropiifolius is an endemic specie in northeast of Brazil. It is renowned for its medicinal properties, larvicidal, insecticidal and cytotoxic activity. This study evaluated the phytochemical screening of ethanolic extract stem bark of C. heliotropiifolius (EECroton) and the toxicological potential in Swiss albino mice. Phytochemical analysis were performed by thin-layer chromatography. The EECroton at 2000 mg/kg (orally) was used for acute toxicity on Swiss albino mice evaluated during a 14-day period. Histomorphometric analysis of liver and renal tissue along with hematological and serum enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), creatinine and urea were measured. The phytochemical investigation of EECroton revealed the presence of coumarins, flavonoids triterpenes and absence of alkaloid, saponins and condensed tannins. The EECroton (2000 mg/kg: o.v.) showed moderate toxicity and the results of serum hematological and enzymatic levels were similar in the respective groups. Histopathological and histomorphometric analyzes confirmed a low of level of toxicity, showing organization of the structural units of the cells, nuclei and sinusoidal capillaries of the hepatocytes as well as renal corpuscles without presenting morphological damage to their organs. These data suggest that the presence of phenolic compound in EECroton demonstrate low order of toxicity.

No Brasil a taxa de mortalidade por câncer no colo do útero é elevada, tendo como principal fator de risco a infecção pelo Papilomavírus humano. O exame de Papanicolau é a técnica mais utilizada para a investigação das lesões precursoras deste câncer. O objetivo do estudo é avaliar a prevalência de alterações citológicas no colo do útero em mulheres situadas na faixa etária de 15 a 59 anos, em Recife – PE, no período de Janeiro de 2010 a Dezembro de 2012. Trata-se de um estudo Epidemiológico, com coleta de dados no SISCOLO/DATASUS. Os dados foram importados e analisados a partir do número de casos, lesão e faixa etária, sendo calculado o percentual e coeciente de prevalência.