A method to obtain tetrahydroisoquinolines (THIQs) fused
to tetrahydrofuran
rings from aminosugar derivatives has been developed. The procedure
relies on a key deprotection of benzyl ethers followed by a double-cyclization
sequence, using FeCl3 as the sole reagent. This tandem
reaction affords the construction of novel fused polycyclic heterocycles
with total stereochemical control.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.