BACKGROUND RS3PE syndrome is a rare rheumatologic disorder characterized by symmetric tenosynovitis of the upper and lower limbs, especially in wrists and metacarpophalangeal, associated with subcutaneous edema of the hand dorsum. The diagnostic criteria are bilateral hand edema, sudden onset of polyarthritis, age more than 50 years, and negative rheumatoid factor. The pathophysiology is still uncertain but responds very well to low doses of corticosteroids with long-term remission, except when it is associated with paraneoplastic syndrome. The objective of this study is to report three cases of idiopathic RS3PE syndrome in patients attending the rheumatology service in a referenced hospital in São Paulo.
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