These results could be of help for individualization of vitamin D supplementation doses in this vulnerable population.
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Depression is a disease of great social and medical im 70.84, p=0.000; psychological health -38.69 versus 69.85, p=0.000; social relations -53.73 versus 64.89, p=0.004; living conditions -54.58 versus 66.7, p=0.000, and in overall quality of life -75.41 versus 96.00, p=0. 49.64 prema 70,84, p = 0,000; psihičko zdravlje-38.69 prema 69.85, p = 0,000; društveni odnosi-53.73 prema 64,89, p = 0,004; život-ni uslovi 54.58 prema 66,7, p = 0,000, kao i ukupan kvalitet života-75.41 prema 96,00, p = 0,000. Rezultati pokazuju da ne postoji statistički značajna razlika u kvalitetu života u zavisnosti od primenjene terapije.Vrednosti ukupnog kvaliteta života depresivnih pacijenata ne zavise od bračnog statusa ili pola ispitanika.Depresivni pacijenti imaju generalno niske vrednosti kvaliteta života u svim pojedinačnim domenima, kao i u ukupnom kvalitetu života. U ime unapređenja mentalnog zdravlja, jedan od primarnih ciljeva treba da bude poboljšanje kvaliteta života depresivnih pacijenata.

No abstract

Vitamin D is one of the keys to bone health, and the serum levels of this vitamin are a major concern for postmenopausal women. The aims of this study were to develop a population pharmacokinetic (PPK) model for the clearance of 25-hydroxy vitamin D in non-elderly postmenopausal women and to identify the factors which have a significant influence on its clearance. The study population consisted of postmenopausal women who had been referred for evaluation of bone mineral density (BMD) by DEXA (dual-energy x-ray absorptiometry) scanner. The population pharmacokinetics modeling was conducted using the ADVAN 1 subroutine from a non-linear mixed effects (NONMEM) program, and thirty-two covariates were assessed. A total of 75 serum concentrations were obtained from the same number of postmenopausal women and used for PPK analysis. The mean value of the participantsí age was 57.92 ± 3.93 years and their body weight was 69.76 ± 11.49 kg. A wide range of 25-hydroxy vitamin D concentrations was observed (from 3.41 to 61.92 ng/mL) with a mean value of 26.19 ± 10.95 ng/mL. A total of 32 covariates were examined and preliminary results suggested the influence of six covariates on 25-hydroxy vitamin D clearance. In the final PPK model, however, only one covariate was shown to have a significant impact on the clearance value ñ the mean daily dietary intake dose of vitamin D (DD). These findings offer a preliminary basis on which to determine the level of vitamin D supplementation required by individual postmenopausal women. It could prove particularly important in achieving optimal serum levels of vitamin D in this vulnerable population.

The aim of this study was to perform screening for anxiety disorders among children with asthma and to reveal factors associated with general anxiety disorder and its specific forms. This was a cross-sectional study conducted among outpatients with asthma during routine visits to pediatricians. They were screened for anxiety disorders using SCARED self-reported questionnaire. Additional data were collected using specially designed questionnaire as well as the patient files. Statistical analysis was performed by the SPPS software using descriptive statistics and logistic regression. Study population consisted mostly of schoolchildren (n=58), 8-12 years old, and adolescents (13-17 years) (n=13). Approximately 33.8% respondents were positive for general anxiety disorder. The most common were separation anxiety and social anxiety, recorded among 49.3% and 32.4% of patients, respectively. Generalized anxiety and panic/somatic disorder were recorded in the same percentage of patients (21.3%), while avoiding school was the least frequent (14.08%). Influence of numerous factors was tested, but only the following showed significant effects: peak expiratory flow test was associated with general anxiety disorder, patient’s age and gender with PD, and living place, asthma control according to GINA and age on GAD. Parent’s smoking was associated with SAD, age and patient’s weight status with SPH, and GINA asthma control with SA. These findings suggest that anxiety disorders are common among children and adolescents with asthma. Various factors can be associated with general anxiety disorder and its specific forms, but some of them being preventable as avoiding smoking in the family.