In this study, we present apatite fission-track results obtained for ten rock samples collected from three different areas across the Sierra Madre del Sur, southern Mexico. The central objective of our study is the timing of the exhumation event that took place in southern Mexico during Late Cretaceous–Palaeogene time. The thermochronometric data obtained during this work indicate that a Late Cretaceous–Eocene cooling is recorded within the Sierra Madre del Sur, and this is interpreted as resulting from exhumation, an orogenic event that is contemporaneous with the Laramide sensu lato (or the Mexican Orogeny). The fission-track ages become younger from west to east across the Sierra Madre del Sur, whereas the cooling rates also increased in the same direction approximately during Campanian–middle Eocene time. Here, we suggest that the activity of the major fault systems of southern Mexico, such as the Caltepec and the Oaxaca faults, played a primary role in the development of geological structures and the exhumation of the Sierra Madre del Sur. Active magmatism during the evolution of the Mexican Orogen implicates the subducted Farallon slab as the main driver of crustal thickening. Moreover, the possible influence of the eastward movement of the Chortis Block on the deformation of the Sierra Madre del Sur cannot be ruled out.
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