The authors enrolled 168 patients with closed-head trauma into a prospective trial to evaluate the effect of hyperbaric oxygen in the treatment of brain injury. Patients were included if they had a total Glasgow Coma Scale (GCS) score of 9 or less for at least 6 hours. After the GCS score was established and consent obtained, the patient was randomly assigned, stratified by GCS score and age, to either a treatment or a control group. Hyperbaric oxygen was administered to the treatment group in a monoplace chamber every 8 hours for 1 hour at 1.5 atm absolute; this treatment course continued for 2 weeks or until the patient was either brain dead or awake. An average of 21 treatments per patient was given. Outcome was assessed by blinded independent examiners. The entire group of 168 patients was followed for 12 months, with two patients lost to follow-up study. The mortality rate was 17% for the 84 hyperbaric oxygen-treated patients and 32% for the 82 control patients (chi-squared test, 1 df, p = 0.037). Among the 80 patients with an initial GCS score of 4, 5, or 6, the mortality rate was 17% for the hyperbaric oxygen-treated group and 42% for the controls (chi-squared test, 1 df, p = 0.04). Analysis of the 87 patients with peak intracranial pressures (ICP) greater than 20 mm Hg revealed a 21% mortality rate for the hyperbaric oxygen-treated patients, as opposed to 48% for the control group (chi-squared test, 1 df, p = 0.02). Myringotomy to reduce pain during hyperbaric oxygen treatment helped to reduce ICP. Analysis of the outcome of survivors reveals that hyperbaric oxygen treatment did not increase the number of patients in the favorable outcome categories (good recovery and moderate disability). The possibility that a different hyperbaric oxygen treatment paradigm or the addition of other agents, such as a 21-aminosteroid, may improve quality of survival is being explored.

We administered hyperbaric oxygen or air in a double-blind prospective protocol to 39 patients with ischemic cerebral infarction. We interrupted the study when we noticed what appeared to be a trend favoring the air-treated patients, whose neurological deficits were less severe (mean±SEM score on graded neurological examination: air, 25.6±4.9; oxygen, 34.5±7.5) and whose infarcts were smaller (air, 29.0±12.2 cm 3 ; oxygen, 49.2 ±11.7 cm 3 ) at 4 months. The trend, we decided, was probably an artifact of the randomization process. Nevertheless, we chose not to resume the trial because the treatment was difficult to administer by schedule (for various reasons the treatment protocol was broken in 15 of the 39 patients), was poorly tolerated (eight of the 39 patients refused to continue treatments), and did not produce dramatic improvement (Stroke 1991^2:1137-1142)

A subarachnoid catheter (SAC) technique of continuous intracranial pressure (ICP) monitoring is presented and compared to intraventricular catheters (IVC's) and subarachnoid bolts (SAB's) in 40 neurosurgical patients. Thirty-one patients were monitored simultaneously with SAC's and IVC's and nine patients with SAC's and SAB's, and the ICP waveforms and measurements were compared. The duration of monitoring ranged from 15 hours to 11 days, and the initial ICP from 2 to 117 torr. A total of 42 SAC's were placed; two that entered brain parenchyma were redirected. One SAC placement was associated with an intracerebral hematoma. There were no infections. For the 31 patients with SAC's and IVC's, there were 2706 pairs of ICP measurements with a mean difference of -0.12 torr and a standard deviation of 5.29 torr. The waveforms from the SAC's and IVC's were indistinguishable. For the nine patients with SAC's and SAB's, there were 773 pairs of ICP measurements with a mean difference of 1.24 torr and a standard deviation of 32.83 torr. The SAB waveforms were of varying quality and all dampened with time. The paired t-test (ts) demonstrated no statistically significant difference between SAC's and IVC's (ts = - 1.19). An analysis of variance demonstrated the scatter of the measurements obtained from SAB's to be 38.5 times that of SAC's, p less than 0.00005. The SAB is shown to be relatively inaccurate with a wide range of variance, while the SAC is demonstrated to be an accurate, reliable, and safe method of continuous ICP measurement and an acceptable alternative to ventriculostomy.

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