Introduction: Agony can be defined as the preciding stage to death, in those situations where life is gradually extinguished. So that, agony is characterized by the cese of the vital functions. From the moment of death and throughout the decomposition process, a series of observable postmortem changes occur in the corpse. Early postmortem changes are rigor mortis, livor mortis, algor mortis and cornea drying. Aim:The aim of the present observational study is to monitor the clinical signs presented during agony and to determine those that are considered as early postmortem changes.Material and methods: Signs monitoring and data registration were carried out during 4 months at the Intensive Care Unit of Hospital of Blanes (Girona, Spain), 21 patients were daily evaluated during their stay at the hospital until the moment of their death. The inclusión criteria for the individuals enrolled in the study were: i) Being diagnosed of a terminal disease and ii) Being at the end of life period. The evaluated signs were: Pallor and cianosis, body temperature, lividities, rigidity, apnea, oral secretions, anuria, eye dehydratation.Results: General pallor was registered in 14 patients, 5 patients presented cyanosis. 12 patients presented rigidity in the cervical region, 5 patients presented rigidity in upper extremity and 8 individuals presented rigidity in the lower extremity; Lividities in upper extremities could be observed in 5 patients, and 7 patients presented lividities in lower extremities. Eye dryness was observed in 10 patients. All those signs are considered postmortem changes. Conclusion:This article highlights the concept of death as a process. And it should be taken into account either by healthcare professionals dealing with the living, in their late stage of life, and also by forensic scientist dealing with the dead.