An intra-intermolecular iron-catalyzed aminoazidation
of non-activated
alkenes is reported for the preparation of imidazolidinone, oxazolidinone,
and pyrrolidinone derivatives. The method uses cheap and abundant
iron as a catalyst and commercially available TMSN3 as
an azide source. This domino process allows, in a single operating
step, for a ring-closure that generates an aza-heterocycle and the
introduction of an azido appendage tethered to the heterocycle. The
conditions developed offer a sustainable alternative method for the
preparation of unsymmetrical vicinal diamine compounds.
A scalable synthesis of Pd-NHC cinnamyl complexes supported on a benzyloxycalix[8]arene is reported. These catalysts are very active for Buchwald-Hartwig cross-coupling reactions, allowing the coupling of aryl chlorides and bromides...
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