A chiral 1,2-amino alcohol derivative, (S)-(+)-2-(N-benzylamino)butan-1-ol (BAB), was synthesized from its Schiff base by catalytic hydrogenation over palladium on carbon, in various solvents (toluene, methanol, hexane, dichloromethane, tetrahydrofuran, ethyl acetate), under mild conditions (room temperature, atmospheric pressure). Preparation of the Schiff base was also optimized. This compound is a resolving agent for preparing optically active, practically important cyclopropanecarboxylic acids.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.