A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.

No abstract

The advent of quantum computing threatens to break many classical cryptographic schemes, leading to innovations in public key cryptography that focus on post-quantum cryptography primitives and protocols resistant to quantum computing threats. Lattice-based cryptography is a promising post-quantum cryptography family, both in terms of foundational properties as well as in its application to both traditional and emerging security problems such as encryption, digital signature, key exchange, and homomorphic encryption. While such techniques provide guarantees, in theory, their realization on contemporary computing platforms requires careful design choices and tradeoffs to manage both the diversity of computing platforms (e.g., high-performance to resource constrained), as well as the agility for deployment in the face of emerging and changing standards. In this work, we survey trends in lattice-based cryptographic schemes, some recent fundamental proposals for the use of lattices in computer security, challenges for their implementation in software and hardware, and emerging needs for their adoption. The survey means to be informative about the math to allow the reader to focus on the mechanics of the computation ultimately needed for mapping schemes on existing hardware or synthesizing part or all of a scheme on special-purpose har dware.

The students' hands were contaminated before taking food. Although they washed hands before meals, they hardly used soap due to non-availability of soap. The school authority should be asked to keep soaps in the toilets for hand washing.

Abstract. We present a method to convert (i) an operational semantics for a given machine language, and (ii) an off-the-shelf theorem prover, into a high assurance verification condition generator (VCG). Given a program annotated with assertions at cutpoints, we show how to use the theorem prover directly on the operational semantics to generate verification conditions analogous to those produced by a custom-built VCG. Thus no separate VCG is necessary, and the theorem prover can be employed both to generate and to discharge the verification conditions. The method handles both partial and total correctness. It is also compositional in that the correctness of a subroutine needs to be proved once, rather than at each call site. The method has been used to verify several machine-level programs using the ACL2 theorem prover.