Antibacterial screening of graphene-tin oxide nanocomposites synthesized from carbonized wood and coconut shell is investigated against Pseudomonas aeruginosa for the first time. Efficient and facile one step hydrothermal process adopted in the present work for the synthesis of graphene-tin oxide nanoparticles provides an ideal method for the economic large-scale production of the same. Graphene-tin oxide nanocomposites derived from wood charcoal possess a spherical morphology whereas rod like structures are seen in the case of coconut shell derivatives. An excitation independent fluorescence response is observed in graphene-tin oxide nanohybrids while graphene oxide nanostructures exhibited an excitation dependent behavior. These hydrophilic nanostructures are highly stable and exhibited no sign of luminescence quenching or particle aggregation even after a storage of 30 months. Bactericidal effects of the nanostructures obtained from coconut shell is found to be relatively higher compared to those procured from wood. This variation in antibacterial performance of the samples is directly related to their morphological difference which in turn is heavily influenced by the precursor material used. MIC assay revealed that coconut shell derived graphene-tin oxide composite is able to inhibit the bacterial growth at a lower concentration (250 μg/mL) than the other nanostructures. Nanocomposites synthesized from agro-waste displayed significantly higher antimicrobial activity compared to the precursor and graphene oxide nanostructures thereby making them excellent candidates for various bactericidal applications such as disinfectants, sanitary agents etc.
Plumbago is a genus of medicinal plants that are used in recent years to induce significant levels of apoptosis in various cancer cells. Purpose: The test substances that are obtained from Plumbago species are studied for their cytotoxicity against U87 cell line in a dose dependent manner and were first subjected to GC-MS study to know the bioactive constituents present in them. Methods: GC-MS was done using ethanol extracts of the roots of both the species. In vitro cytotoxicity of the roots of two species of Plumbago -P. zeylanica (sample I) and P. auriculata (sample II) were tested against U87 cell line. Test samples were taken at concentrations ranging from 400μg/ml to 3.12μg/ml to determine the percentage growth inhibition of both the test substances on U87 cell line. Results: GC-MS analysis on root extracts of P. zeylanica showed the presence of 27 phytochemical constituents and P. auriculata 16 in number .The test substances, Sample I and Sample II exhibited a cytotoxic CTC 50 value of 88.07±4.4 and 23.11±0.9 respectively. Conclusion: P. zeylanica is more effective than P. auriculata in terms of its cytotoxicity as well in the number of useful bioactive compounds.
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