Background:The aim was to collate and contrast patient concerns from a range of different head and neck cancer follow-up clinics around the world.Also, we sought to explore the relationship, if any, between responses to the patient concerns inventory (PCI) and overall quality of life (QOL). Methods: Nineteen units participated with intention of including 100 patients per site as close to a consecutive series as possible in order to minimize selection bias.Results: There were 2136 patients with a median total number of PCI items selected of 5 (2-10). "Fear of the cancer returning" (39%) and "dry mouth" (37%) were most common. Twenty-five percent (524) reported less than good QOL.Conclusion: There was considerable variation between units in the number of items selected and in overall QOL, even after allowing for case-mix variables.There was a strong progressive association between the number of PCI items and QOL.
K E Y W O R D Shead and neck cancer, patient concerns inventory, patient prompt list, quality of life
A titanium implant surface when coated with biodegradable, highly porous, osteogenic nanofibrous coating has shown enhanced intrinsic osteoinductive and osteoconductive properties. This coating mimics extracellular matrix resulting in differentiation of stem cells present in the peri-implant niche to osteoblast and hence results in enhanced osseointegration of the implant. The osteogenic nanofibrous coating (ONFC) consists of poly-caprolactone, gelatin, nanosized hydroxyapatite, dexamethasone, ascorbic acid and beta-glycerophosphate. ONFC exhibits optimum mechanical properties to support mesenchymal stem cells and steer their osteogenic differentiation. ONFC was subjected to various characterization tests like scanning electron microscopy, Fourier-transform infrared spectroscopy, x-ray diffractometry, thermal degradation, biomineralization, mechanical properties, wettability and proliferation assay. In pre-clinical animal trials, the coated implant showed enhanced new bone formation when placed in the tibia of rabbit. This novel approach toward implant bone integration holds significant promise for its easy and economical coating thus marking the beginning of new era of electrospun osteogenic nanofibrous coated bone implants.
stained with haematoxylin (HiMedia, India)-eosin (HiMedia, India), and examined under optical microscopes (Stereozoom microscope LM-52-3611, Lynxinst, India and Olympus BX53M, Olympus Corp., Tokyo, Japan) for analysis of regenerated osseous tissue. Bone-to-implant contact was measured by dividing the bone contact perimeter by the total perimeter of the implant 88. Statistics. All numerical data were expressed as mean ± standard error of mean (SEM). Statistical analysis was performed using OriginPro software (OriginLab Corporation). Obtained data sets were first subjected to Kolmogorov-Smirnov test to check their distribution. Accordingly, Student's t-test was performed for parametric data sets and P < 0.05 was considered statistically significant.
Background:Treatment of acute leukemia's- a common childhood malignancy, involves intensive and powerful multi-drug chemotherapeutic regime. Oral lesions are a common complication in these patients affecting oral health status.Aim:This study was conducted to evaluate and assess the oral health status of newly diagnosed leukemic pediatric patients during induction phase and its correlation to outcome of induction therapy.Material Methods:Oral examinations was done in 33 children between the age group of 5-15 years with acute lymphoblastic leukemia (ALL) and acute myloblastic leukemia (AML), who were undergoing chemotherapy. Oral Hygiene Index- Simplified, (OHI-S) decayed missing filled teeth index (def/DMFT), Loe and Sillness index for gingiva, and complete blood count at first and fourth week of induction phase were recorded for each patient. The changes in the oral health status were analyzed with Wilcoxon signed rank test.Results:During an induction phase it was observed that level of OHI-S (P = 0.002), Loe and Sillness index (P = 0.003), def/DMFT index (P = 0.076), platelet count (P = 0.00) increased significantly and no significant difference was noted in hemoglobin (P = 0.4) and total leucocytes count (P = 0.11).Conclusion:It was observed that, although oral health status had significantly worsened, the induction outcome was not affected.
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