Background Cancer is the leading cause of morbidity and mortality worldwide. It encompasses a large family of diseases exhibiting abnormal cell growth with the potential to invade or spread to other part of the body. Natural extracts have been used as an efficient anticancer agent that show promising results. In this, study the cytotoxicity and anticancer effect of Ayurvedic herbal extract code name V2S2 was studied and compared with control drug Adriamycin that is an established chemotherapeutic drug.
Materials and Methods Ayurvedic coded drug V2S2 is a hydroalcoholic extract of herbs. The in vitro anticancer study was performed with sulforhodamine B assay in TATA Memorial, ACTREC Mumbai as per National Cancer Institute guidelines.
Result GI50 of V2S2 study drug and Adriamycin on COLO-205, HOP-62, K-562, ISHIKAWA, HeLa, MCF-7, SCC-40, Hep-G2 and MIA-PA-CA-2 is less than 10 that means both drugs have equal anticancer activity.
Conclusion The study group has more and less equal potential of anticancer activity in compared with a transient's standard anticancer drug. Moreover, in vitro monkey kidney normal cell line study drug V2S2 shows same cytotoxicity as shown by control drug Adriamycin.
Ayurveda is one of the ancient and holistic system of Medicine. It is a system where principles of living and treatment are described in codified form. Rasashastra and Bhaishajya kalpana is a branch of Indian Alchemy and Iatrochemistry. In this branch number of herbo-mineral and purely herbal formulations are mentioned with wide range of dosage forms. It is not only a science of drug manufacturing but also the science of selection, identification, prevention and standardization. A good quality of products assures the anticipated results. The pharmaceutical preparations when prepared with proper scientific approach it can prove to be a boon for patients. Amavatari rasa and Rasnadi guggulu are amongst the important preparations, which have been mentioned in well-known rasa text Brihat yog tarangini and Bhaishjya ratnavali. Pharmaceutical study involves preparation of Amavatari Rasa and Rasnadi Gugglu according to classical method. All the raw materials were procured from the Pharmacy of N.I.A, Jaipur and Pharmaceutical procedures were carried out in the department of Rasa Shastra and Bhaishajya Kalpana, NIA Jaipur.
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