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Seborrheic keratosis is a benign epidermal neoplasm, representing one of the most common skin tumors. Clonal seborrheic keratosis is one of the histological subtypes of this entity. It is an uncommon lesion which may resemble other benign or malignant lesion. We report a case of a 60-year-old woman presented with a 7 year history of a gradually growing, cutaneous lesion on her left arm. On physical examination, the lesion was elevated, well-circumscribed, measuring 5 cm in maximum diameter. The tumor was biopsied. Histopathological examination revealed the presence of well-defined nests of clear-looking or basaloid keratinocytes within an acanthotic epidermis, corresponding to the Borst-Jadassohn phenomenon. The tumor cells were small and monomorphic. We diagnosed this tumor as clonal seborrheic keratosis. Although surgical excision was recommended, our patient refused an operation. This case of clonal seborrheic keratosis is presented for its rarity and for differential diagnosis.

La gastrite chronique à Helicobacter pylori (H pylori) présente un risque de cancérisation en rapport avec l'atrophie et la métaplasie intestinale. Deux nouvelles classifications, OLGA (Operative Link on Gastritis Assessment) et OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) ont été proposées pour individualiser les formes à haut risque évolutif (stades III et IV). Le but de ce travail est d’évaluer les classifications de OLGA et de OLGIM au cours des gastrites chroniques à H pylori. Nous avons réalisé une étude descriptive transversale portant sur 100 cas de gastrite chronique à H pylori. La réévaluation des paramètres du Sydney System de l'atrophie et de la métaplasie intestinale, de l'antre et du corps gastrique, a permis de définir respectivement les stades OLGA et OLGIM. Le risque évolutif de nos gastrites à H pylori était de 6% selon OLGA et de 7% selon OLGIM. Une liaison significative a été révélée entre l’âge et OLGA. Les gastrites à haut risque selon OLGIM, étaient significativement associées à une atrophie modérée à sévère. Les formes à haut risque selon OLGA s'associaient dans plus de 80% des cas à une métaplasie intestinale. OLGA et OLGIM présentaient une corrélation positive et hautement significative entre elles avec une discordance évaluée à 5%. Les classifications de OLGA et OLGIM, en complément au Sydney System, permettent de sélectionner les formes de gastrites à haut risque nécessitant une surveillance étroite.

Schwannomas are generally benign, slow growing tumors. They are rarely observed in the gastrointestinal tract with the most common site being the stomach. These tumors are usually asymptomatic. The preoperative diagnosis via endoscopy is a challenging issue due to the difficulty of differentiation from other submucosal tumors. A 54-year-old woman presented with epigastric pain persisting for the last 10 months. Upper endoscopy revealed an elevated submucosal mass of the gastric antrum. The overlying mucosa was normal. Biopsy specimens yielded only unspecific signs of mild inactive chronic inflammation. Endoscopic ultrasound examination noted a hypoechoic homogeneous mass lesion located in the gastric antrum. The mass appeared to arise from the muscularis propria, and there was no perigastric lymphadenopathy. A contrast-enhanced computed tomography scan identified a homogeneous round mass and arising from the antrum of the stomach. Submucosal tumor was suspected and surgical intervention was recommended. The patient underwent an elective laparoscopic partial gastrectomy. The histopathologic features and immunohistochemical-staining pattern were consistent with a benign gastric schwannoma. Our patient shows no recurrence with a follow-up of one year. The definitive diagnosis of gastric schwannomas requires immunohistochemical studies. Complete margin negative surgical resection, as in this case, is the curative treatment of choice. The clinical course is generally benign.

125 estimations. Twenty-three had histologic diagnosis of EOC. NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count. Data were analyzed using SPSS version 20. The correlation between NLR and CA-125 levels was determined using the Spearman's correlation coefficient. Elevated NLR was defined as a value ! 2.23. Results The mean age of the participants was 51.43± 11.08 years .The median serum CA-125 level was 264 IU/L and the interquartile range was 97.3-554.4. The NLRs ranged from 1.4 to 3.6 with a median value of 2.23. There was no correlation between NLR and p=0.364). Conclusions Though this study did not demonstrate any relationship between NLR and CA-125 in patients with EOC, it may find usefulness as a biomarker in the future if subjected to further research.

Retroperitoneal paragangliomas are relatively rare endocrine tumours derived from the extra-adrenal paraganglia of the autonomic nervous system. They can be functional when they secrete catecholamines or non-functional. The diagnosis of a paraganglioma is infrequently made preoperatively unless the tumour is functional. In this paper, the authors report a new case of non-functional paraganglioma. A 54-year-old woman with a past medical history of viral hepatitis, presented with vague abdominal pain of five years' duration. On examination, no abdominal mass was palpable and her blood pressure was 100/60 mm Hg. Abdominal computed tomography scan demonstrated a well-defined hypervascular retroperitoneal mass of heterogeneous density in the left para-aortic region measuring 3cm in diameter. As paraganglioma was suspected preoperatively, serum and urine cathecholamine levels were performed and were within normal range. Complete surgical excision of this mass was performed. Histological examination of the surgical specimen coupled with immunohistochemical study was consistent with the diagnosis of pararganglioma. Retroperitoneal paragangliomas are most commonly benign with good prognosis, but can be locally invasive and metastasize as well. The possibility for malignant transformation of paragangliomas makes surgical excision the treatment of choice. [J Interdiscipl Histopathol 2013; 1(3.000): 168-171