1311-labeled human serum amyloid P component, which was injected into mice with experimentally induced systemic AA amyloidosis and into controls, became specifically localized and was retained in amyloidotic organs. In comparison, it was rapidly and coimpletely eliminated from unaffected tissues and from control animals. Distinctive images of this amyloidspcecific deposition of labeled serum amyloid P component were derived from whole body scanning, in vivo, of amyioidotic mice. These findings suggest that such im-
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