M.W. (2015) 'Applying green chemistry to the photochemical route to artemisinin.', Nature chemistry., 7 (6). pp. 489-495. Further information on publisher's website:https://doi.org/10.1038/nchem.2261Publisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

The Facility for Rare Isotope Beams (FRIB) Project has entered the phase of beam commissioning starting from the room-temperature front end and the superconducting linac segment of first 15 cryomodules. With the newly commissioned helium refrigeration system supplying 4.5[Formula: see text]K liquid helium to the quarter-wave resonators and solenoids, the FRIB accelerator team achieved the sectional key performance parameters as designed ahead of schedule accelerating heavy ion beams above 20[Formula: see text]MeV/u energy. Thus, FRIB accelerator becomes world’s highest-energy heavy ion linear accelerator. We also validated machine protection and personnel protection systems that will be crucial to the next phase of commissioning. FRIB is on track towards a national user facility at the power frontier with a beam power two orders of magnitude higher than operating heavy-ion facilities. This paper summarizes the status of accelerator design, technology development, construction, commissioning as well as path to operations and upgrades.

This article analyzes dimensional changes due to irradiation of monolithic plate-type nuclear fuel and compares results with finite element analysis of the plates during fabrication and irradiation. Monolithic fuel plates tested in the Advanced Test Reactor (ATR) at Idaho National Lab (INL) are being used to benchmark the performance of proposed fuel for several high power research reactors. Post-irradiation metallographic images of plates sectioned at the mid-plane were analyzed to determine dimensional changes of the fuel and the cladding response. A constitutive model of the fabrication process and irradiation behavior of the tested plates was developed using the general purpose commercial finite element analysis package, ABAQUS. Using calculated burn-up profiles of irradiated plates to model the power distribution and including irradiation behaviors such as swelling and irradiation enhanced creep, model simulations allow analysis of plate parameters that are either impossible or infeasible in an experimental setting. The development and progression of fabrication induced stress concentrations at the plate edges was of primary interest, as these locations have a unique stress profile during irradiation. Additionally, comparison between 2D and 3D models was performed to optimize analysis methodology. In particular, the ability of 2D and 3D models to account for out of plane stresses which result in 3-dimensional creep behavior that is a product of these components. Results show that assumptions made in 2D models for the out-of-plane stresses and strains cannot capture the 3-dimensional physics accurately and thus 2D approximations are not representative. Stress-strain fields are dependent on plate geometry and irradiation conditions, thus, if stress based criteria is used to predict plate behavior (as opposed to material impurities, fine micro-structural defects, or sharp power gradients), unique 3D finite element formulation for each plate is required.

This article aims to provide possible mechanical causes for the lowered blister temperatures of RERTR-12 and AFIP-4 fuel plates. Recent experimental investigations to determine the blister threshold temperatures have indicated lower thresholds for similar plates with comparable burn-up histories. Measured blister temperatures of roughly 100 °C lower compared to the previously tested plates may not be satisfactory for some plates. The primary differences between recent experiments and previous tests are: (1) An aggressive cold work process involving large thickness reduction ratios without normalization or full annealing (2) Subjecting the plates to a thermal cycling process prior to irradiation, and finally (3) A primarily frontal neutron flux as opposed to a transverse flux profile. It is believed that the stress field has implications to blister behavior. To investigate this claim, the stress-strain states for the fabrication procedure were evaluated. First, the residual stress profile caused by the cold rolling process was calculated. Modeling of the cold rolling process has shown confirmation of residual stresses of considerable magnitude and the existence of stress gradients with respect to foil thickness prior to the HIP process. Once calculated, these stress profiles were used as an initial condition for the fabrication process. Due to the variation in stress fields depending on location at which a foil is cut from the cold rolled plate, three representative regions were selected and implemented in the HIP simulation. Variation in stresses, depending on location of the cold rolled plate as well and variation in the through-thickness, results in a wide range of mechanical stress states. This suggests that inhomogeneous irradiation and thermal cycling behavior will result from the use of cold rolled foils. Additionally, these results suggest that there will be fundamental differences in fuel plate behavior observed between plates fabricated with cold rolled foils versus hot rolled and fully annealed foils.

The combination of continuous-flow processing with heterogeneous catalysts allows for efficient, sustainable, multistep synthesis. Here, we report the continuous-flow synthesis of a valuable terpene product, phellandrene, from a readily available natural feedstock. The protocol consists of selective hydrogenation using a highly active and stable supported platinum catalyst, dehydrative hydrazone formation, followed by the Shapiro reaction. Appropriate design of the reactor allowed for high productivity and space−time yield. Phellandrene was synthesized on a 30-g scale over 6 h, giving high yields, purity, and productivity.