A zirconium-catalyzed hydroaminoalkylation of alkynes to access α,β,γ-substituted allylic amines in an atomeconomic fashion is reported. The reaction is compatible with N-(trimethylsilyl)benzylamine and a variety of N-benzylaniline substrates, with the latter giving the allylic amine as the sole organic product. Various internal alkynes with electron-withdrawing and electron-donating substituents were tolerated. Model intermediates of the reaction were synthesized and structurally characterized. Stoichiometric studies on key intermediates revealed that the open coordination sphere at zirconium, imparted by the tethered bis(ureate) ligand, is crucial for the coordination of neutral donors. These complexes may serve as models for the inner-sphere protonolysis reactions required for catalytic turnover.
The reductive coupling of alcohols using vanadium pyridonate catalysts is reported. This attractive approach for C(sp 3 )−C(sp 3 ) bond formation uses an oxophilic, earth-abundant metal for a catalytic deoxygenation reaction. Several pyridonate complexes of vanadium were synthesized, giving insight into the coordination chemistry of this understudied class of compounds. Isolated intermediates provide experimental mechanistic evidence that complements reported computational mechanistic proposals for the reductive coupling of alcohols. In contrast to previous mononuclear vanadium(V)/vanadium(III)/vanadium(IV) cycles, this pyridonate catalyst system is proposed to proceed by a vanadium(III)/vanadium(IV) cycle involving bimetallic intermediates.
The intermolecular
hydroamination of alkenes with alkylamines has
been a long-standing challenge in catalysis, partially due to the
near-thermoneutral nature of this transformation. Consistent with
this understanding, we report the direct observation of reversible
C–N bond formation in hydroamination. A bis(ureate) zirconium
complex catalyzed the intermolecular hydroamination of 2-vinylpyridine.
Reversible C–N bond formation was characterized by variable-temperature
NMR spectroscopy, and thermodynamic parameters were determined using
van’t Hoff plots. Isolated intermediates support an aza-Michael-addition
mechanism. Sensitivity to steric bulk in the C–N bond forming
step provided further evidence for the kinetically accessible but
limited thermodynamic driving force for this transformation.
The synthesis, structure, and reactivity of vanadium pyridonate complexes are described. Vanadium(III) pyridonate complexes were accessed through protonolysis and reduction of a tetrakis(amido)vanadium(IV) starting material. Bis(pyridonate) vanadium(IV) precursors could be...
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