La salud en Colombia es ahora un derecho fundamental que tiene que ser provisto y protegido por el Estado. A partir de metodologías de análisis de sistemas de salud propuestospor la OMS y el Banco Mundial, se evidencian las falencias, fortalezas y dificultades del sistema de salud con respecto ala ley estatutaria aprobada en febrero de 2015. Éstas incluyen la fragmentación y especialización de los servicios, barreras de acceso, incentivos no alineados con la calidad, débil gobernanza, múltiples actores con poca coordinación y sistema de información que no mide resultados. Es necesario un acuerdo social, un equilibrio y control de la tensión por parte del Estado entre el beneficio particular y el beneficio colectivo.

In modeling social interaction online, it is important to understand when people are reacting to each other. Many systems have explicit indicators of replies, such as threading in discussion forums or replies and retweets in Twitter. However, it is likely these explicit indicators capture only part of people's reactions to each other; thus, computational social science approaches that use them to infer relationships or influence are likely to miss the mark. This paper explores the problem of detecting non-explicit responses, presenting a new approach that uses tf-idf similarity between a user's own tweets and recent tweets by people they follow. Based on a month's worth of posting data from 449 ego networks in Twitter, this method demonstrates that it is likely that at least 11% of reactions are not captured by the explicit reply and retweet mechanisms. Further, these uncaptured reactions are not evenly distributed between users: some users, who create replies and retweets without using the official interface mechanisms, are much more responsive to followees than they appear. This suggests that detecting non-explicit responses is an important consideration in mitigating biases and building more accurate models when using these markers to study social interaction and information diffusion.

Paraneoplastic conditions such as cancer cachexia are often exacerbated by chemotherapy, which affects the patient’s quality of life as well as the response to therapy. The aim of this narrative review was to overview the body-composition-related changes and molecular effects of different chemotherapy agents used in cancer treatment on skeletal-muscle remodeling. A literature search was performed using the Web of Science, Scopus, and Science Direct databases and a total of 77 papers was retrieved. In general, the literature survey showed that the molecular changes induced by chemotherapy in skeletal muscle have been studied mainly in animal models and mostly in non-tumor-bearing rodents, whereas clinical studies have essentially assessed changes in body composition by computerized tomography. Data from preclinical studies showed that chemotherapy modulates several molecular pathways in skeletal muscle, including the ubiquitin–proteasome pathway, autophagy, IGF-1/PI3K/Akt/mTOR, IL-6/JAK/STAT, and NF-κB pathway; however, the newest chemotherapy agents are underexplored. In conclusion, chemotherapy exacerbates skeletal-muscle wasting in cancer patients; however, the incomplete characterization of the chemotherapy-related molecular effects on skeletal muscle makes the development of new preventive anti-wasting strategies difficult. Therefore, further investigation on molecular mechanisms and clinical studies are necessary.

No abstract

O artigo explora a tese de que a ordem constitucional vigente sob a Constituição Federal de 1988 é caracterizada pela indeterminação social do direito. Esse conceito combina dimensões empíricas e normativas: a multiplicidade de arenas decisórias especializadas na estabilização de expectativas e a luta de justificação sobre a interpretação política das normas jurídicas.

Online communities provide a fertile ground for analyzing people's behavior and improving our understanding of social processes. Because both people and communities change over time, we argue that analyses of these communities that take time into account will lead to deeper and more accurate results. Using Reddit as an example, we study the evolution of users based on comment and submission data from 2007 to 2014. Even using one of the simplest temporal differences between users-yearly cohorts-we find wide differences in people's behavior, including comment activity, effort, and survival. Further, not accounting for time can lead us to misinterpret important phenomena. For instance, we observe that average comment length decreases over any fixed period of time, but comment length in each cohort of users steadily increases during the same period after an abrupt initial drop, an example of Simpson's Paradox. Dividing cohorts into sub-cohorts based on the survival time in the community provides further insights; in particular, longer-lived users start at a higher activity level and make more and shorter comments than those who leave earlier. These findings both give more insight into user evolution in Reddit in particular, and raise a number of interesting questions around studying online behavior going forward.

No abstract

No abstract