Background: Oral contraceptive pill (OCP) is related to development of hypercoagulability and the risk of thromboembolic effects in women. Objectives: To assess the coagulability status in women taking oral contraceptives by estimation of plasma fibrinogen level and total count of platelets. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2012 to December 2012 on sixty apparently healthy female subjects aged 25 to 45 years taking OCP -s for 1 to 10 years. Thirty subjects were 1 to 5 years user group and another 30 subjects were >5 to 10 years user group. They were collected from family planning clinics of Dhaka city. In addition, age matched 30 apparently healthy women of OCP nonusers were also studied as control. For assessment of coagulability state, plasma fibrinogen and total counts of platelet levels were estimated by automated coagulation analyzer and automated hematology analyzer. Statistical analysis was done by unpaired Student's t' test. Results: The mean (±SE) total count of platelet level was significantly higher (P<0.001) in contraceptive user group and plasma fibrinogen level was higher in users but it was not significant. Conclusion: This study concludes that OCP users had more tendency of hypercoagulability and therefore these women are at higher risk of thromboembolic effects.
Background: Birth control pills alter women's reproductive cycle and suppress various endocrine functions. Primary alterations of endocrine functions have secondary effects on other chemical and enzyme functions of the body. A general lowering of the body's nutrient base occurs in women on hormonal contraception.The biochemical profile of oral contraceptive pill user women showed different changes in plasma total protein, albumin and various trace minerals like serum zinc, copper, magnesium etc. Trace minerals are necessary for endocrine function. This study was designed to evaluate serum zinc levels of women taking oral contraceptives. Methods:This cross-sectional study was conducted A total of 150 subjects were included in this study; among them 50women were selected as control (Group I),who were neither taking oral contraceptives at the time of selection nor had taken it during prior one year period and 100 women were included as case (Group II), those were taking oral contraceptives. Again Group II was divided as Group IIA included 50 women who were taking oral contraceptives for 3 months duration or less and Group IIB included 50 women who were taking oral contraceptives for 4 months -5years duration. Student's unpaired't' test was used to analyze the data between groups. For analytical purpose 95% confidence limit (p<0.05) was taken as level of significance.Results: In this study, mean±SD of serum zinc was found as 84±13.33ìgm/dl, 57.88±3.68ìgm/dl and 58.40±4.59ìgm/dl in Group I, Group IIA and Group II B respectively. Serum zinc was significantly low in both Groups IIA and IIB in comparison to Group I (p<0.001). Conclusion:In this study serum zinc level was significantly lower in women taking OCP in comparison with control individuals who were not taking any hormonal contraceptive.
This study was done to assess the hypercoagulability and the risk of thromboembolism in women taking oral contraceptive pill for prolonged period of time. This cross sectional study was done in the department of Physiology, Dhaka Medical College, Dhaka from Jan 2012 to Dec 2012. Ninety female subjects with the age range from 25-45 years, were taken as a study population. Among them, 60 women taking oral contraceptives for prolonged period of time ( > 1 years) were included for the study group and age matched 30 women of OCP nonusers were taken as a control. Study subjects were divided into two groups according to their duration of oral pill use: group BI ( 1 to 5 years users) were 30 women and group B2 ( >5 to 10 years users) were 30 women. Prothrombin time and activated partial thromboplastin time were estimated in all groups. Statistical analysis was done by unpaired Student's ? t' test and Pearson's Correlation Coefficient test. In this study, the mean (*SD) PT levels in group B1 & B2 were shortened than that of group A which were statistically highly significant (P < 0.001). Within the study groups, PT levels were positively correlated (r=+0.027) with the group B1 and negatively correlated (r= -0.163) with the group B2. But both the relationships were statistically non significant. The mean (+SD) AM' level in group B1 was shortened than that of group A but the result was not statistically significant. The mean (*SD) AM' level in group B2 was shortened than that of group A but the result was statistically highly significant (P<0.001). Within the study groups, APPT levels were negatively correlated with the group B1 (r= -0.268) and also group B2 (r= -0.122). But both the relationships were statistically non significant. My present study revealed that prolonged duration of OCP use ( at least for 5 years) increases the risk of hypercoagulable state and thromboembolism in women.
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