Introduction: In elderly patients, the prevalence of chronic diseases, including chronic obstructive pulmonary disease, is increased. COPD causes many problems, including dyspnea, fatigue, depression, malnutrition and limitation in daily activities and death anxiety among patients that can affect their self-care. Method: This study considered as a descriptive-correlation study in 128 elderly with COPD that referred to Masih daneshvari hospital in Tehran with accessible sampling method. Research tools were included demographic information questionnaire, Templer death anxiety questionnaire and Elderly self-care questionnaire. Data were analyzed by spss v.16 software using Spearman's correlation test, One-way ANOVA and Independent t-test. Results: Mean and standard deviation total score of death anxiety was 60.09 ± 8.3 in the score range of 15-75. Mean and standard deviation total score of self-care was 94.89 ± 4.85 in the score range of 40-160. Based on the spearman correlation test, there was statistically significant and reverse correlation between death anxieties with selfcare (r =-0.590, P= 0.001). Conclusion: The results of our study showed that the level of death anxiety in elderly patients with COPD was high. Death anxiety in patients has a negative effect on their selfcare ability.
Introduction: Induction of in vitro spermatogenesis can be useful for infertility treatment in azoospermic patients and those undergoing chemotherapy. Different culture systems have been used to achieve this goal. This review study was performed with the aim to evaluate the application of 3D culture and testicular scaffolds in the establishment of in vitro spermatogenesis. In this review study, the information on the application of 3D culture and testicular scaffolds in induction of in vitro spermatogenesis was searched in databases such as SID, Magiran, PubMed, Irandoc, Iranmedx Scopus, Google Scholar, Web of Science using the keywords of three dimensional culture, testicular scaffold, spermatogenesis, spermatogonial stem cells without time limitation. Data analysis was carried out qualitatively. Finally, 35 papers in English and Persian were used to compile the article. In order to induce of in vitro spermatogenesis, three-dimensional culture methods such as testicular tissue culture, soft agar culture system, natural biomaterial scaffolds such as collagen, and scaffolds derived from decellularized testis have been used. Conclusion: Three-dimensional culture using spermatogonial stem cells and scaffolds can be used in vitro for induction of spermatogenesis, but there are further technical and ethical challenges in the path of fertile sperm production for the treatment of infertility.
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