A new series of perfluoroalkylated fatty acid monoesters of a,~trehalose and sucrose has been evaluated with respect to their physicochemical and biological properties for possible biomedical use. These water-soluble compounds strongly reduce the water surface tension and fluorocarbon/water interracial tension. As cc~surfaetants in perfluorodecalin/Pluronic F4}8 type emulsions they significantly increase the stability of these emulsions. Remarkably stable concentrated perfluorodee~qlin-in-water (50% w/v) emulsions were obtained when the CsF]TCH2CH2C(O~a,a-trehalose monoester was used as the sole surfaetant, while no emulsion could be obtained with its maltoside analogue. No significant effect on the growth and viability of Namalva cell cultures and no hemolytic activity on human erythrocytes at concentrations up to 50 g/L were detected for these amphiphiles in spite of their high surface activity. The LDs0 was found to be in the range of 250-375 mg/kg of body weight Lv. in mice.KEY WORDS: Fluorocarbon emulsion, perfluorodecalin emulsion, perfluoroalkylated fatty acid monoester of sucrose, perfluoroalkylated fatty acid monoester of trehalose, perfluoroalkylated stu ~ factant, 6-O-[3'-(perfluorooctyl) propanoyl]-trehalose.
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