Immunosuppressive agents have been recognized as factors that induce changes and modifications in bone metabolism. The purpose of this study was to evaluate the effect of ozonated plant extracts (herein termed ozonated oil) under the influence of Cyclosporin A (CsA) on osseointegration. A total of 20 dental implants were placed in 20 rabbit tibiae assigned to Group A or B. CsA was injected at an immunosuppressive dose in Groups A and B as a single-dose treatment. At the day of surgery, Group A received a single topical ozonated oil treatment (0.55 mL) around dental implants; Group B, the control group, received no ozonated oil. Animals were sacrificed after 8 weeks. Radiographs were obtained at implant surgery and on the day of sacrifice. Bone quality was compared between the 2 groups. Radiographically, osseointegration was microscopically evaluated using scanning electron and light microscopies. In ozonated Group A specimens, light microscopic examination demonstrated evidence of more organized mature bone compared with Group B. Within the limits of this study, the results suggest that short-term administration of CsA, when administered with topical ozonated oil, may influence bone density and the quality of dental implant osseointegration. Therefore, topically applied ozonated oil may influence bone density and the quality of osseointegration around dental implants.

Background This study aimed to analyze the effectiveness of virtually designed polyether‐ether ketone (PEEK) sheets to delineate and maintains the three‐dimensional patient's maxillary alveolar ridge. Materials and methods Fourteen patients (34 implants) with severely atrophied anterior maxillary alveolar ridges underwent rehabilitation using custom‐made CAD/CAM PEEK sheets acting as a containment system for interpositional mix of particulate autogenous and xenogeneic bone graft, fixed by mono‐cortical screws. Radiographic Assessment included measurements of linear changes in the vertical and horizontal dimensions on cross‐sectional cuts of computed tomography (CBCT) using special software. Results Wound healing was uneventful for all the patients except one patient that showed wound break down 2 weeks postoperatively, which did not affect the outcome of the procedure. CBCT scans were interpreted to compare the quantity of both vertical and horizontal bone preoperatively and 6 months postoperatively. Statistical analyses demonstrated a significant difference between the results of both time intervals, with a mean vertical and horizontal bone gain was 3.47 mm(±1.46) and 3.42 (±1.1) with a P‐value of (.0001). The customized sheets were removed 6 months postoperative with the successful placement of dental implants. Conclusion The virtual planning of three‐dimensional maxillary alveolar ridge augmentation utilizing patient‐specific PEEK sheets deemed successful to restore the deficient ridge and to accommodate suitable size dental implants.

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Introduction Anterior disc displacement is one of the most frequent temporomandibular joint (TMJ) disorders, which often results in clicking, joint pain, a limited range of motion and masticatory difficulties.Methodology Four subjects (with a total number of six joints) who had significant pain and dysfunction that did not respond to non-surgical therapy, went into arthroscopic disc repositioning using wire fixation for 3 weeks then it was removed, and the patient continued on occlusal splints.Results After six months postoperatively, there was a significant increase in the MIO (Maximum incisal opening) and an insignificant decrease in the pain perception in the VAS (visual analogue scale) Conclusion The study concluded that arthroscopic temporomandibular joint disc repositioning is an effective minimally invasive procedure for the treatment of some temporomandibular joint internal derangements refractory to conventional conservative therapy in regards to clinical outcomes

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