In recent years, there has been increasing recognition that a number of synthetic polymers which have excellent biodegradability and biocompatibility are materials of pharmaceutical importance in the area of drug delivery technology. The aim of this review is to take a closer look at a few synthetic polymer-based drug delivery systems, specially the aliphatic polyesters, polyamides, polyethers, polyorthoesters, polyanhydrides, polyurethanes, hydrogels and dendritic polymers.
Synthesis of novolac resin based novel network polymer 1 based on the reaction between novolac epoxy resin and ethylenediamine has been achieved for the first time and its sorption characteristics toward methyl orange as azo dye source have been investigated.
Cytotoxicity of both polyamidoamine dendritic diol (PAMAM) and side chain dendritic oligourethane (SCDOU) was studied through interaction with mammalian fibroblast cells (L929). Cell metabolic activity in the presence of dendritic polymers was measured using an MTT assay exhibiting significant cell viability. Additionally, the antibacterial activity of PAMAM dendron, SCDOU, as well as their silver-doped structures was studied against Escherichia coli bacteria. The results showed that the silver-doped structures attain high antibacterial activity. Formation of silver-doped dendritic polymers was investigated from the UV-visible plasmon absorption band of silver particles.
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