<p class="abstract"><strong>Background:</strong> Even though sinusitis is a common clinical entity, its complications are seen rarely after the advent of antibiotics. Hence we aimed to analyse varied clinical presentations and manifestations of orbital involvement in paranasal sinus diseases and their outcome.</p><p class="abstract"><strong>Methods:</strong> Hospital based prospective study done from January 2007 to December 2017. We selected 65 patients in our study based on our inclusion and exclusion criteria. Type of orbital involvement was analysed by computed tomography scan. Immediate aggressive medical management was started and surgery was undertaken if there is no clinical improvement in 48 hours. Endoscopic sinus surgery done along with orbital decompression and drained pus was sent for culture sensitivity. Patients were followed up regularly and suction clearance was done. </p><p class="abstract"><strong>Results:</strong> Out of 65 patients, 50 were male and 15 were female. 24 patients had bacterial pathology, 40 had fungal pathology and 1 patient had non specific inflammatory disease consistent with mucocoele. Out of 24 bacterial sinusitis, 2 had bilateral disease and 1 patient had scalp and neck extension. Out of 40 fungal sinusitis, 2 patients had 6th cranial nerve palsy with sphenoid disease, 5 patients had palatal extension and 8 patients had intracranial involvement.</p><p class="abstract"><strong>Conclusions:</strong> All cases of orbital oedema and proptosis should be thoroughly evaluated for sinus disease. Computed tomography aids to know the extent of disease, deciding about the type and mode of intervention. Early diagnosis and immediate intervention reduces significant mortality and morbidity. However regular follow up, counselling the patients and relatives helps in achieving appropriate outcome.</p>
<p class="abstract"><strong>Background:</strong> Obstructive sleep apnoea (OSA) is characterized by repetitive partial or complete collapse of the upper airway during sleep, which results in disruptions of normal sleep architecture. It is associated with cardiopulmonary consequences like hypertension, myocardial infarction and stroke. Although the pathogenesis of this association remains unclear, an alteration in coagulability is suspected as a linkage. Hence, the present study aims at the reliability of Bleeding time, platelet count, PT, aPTT and INR to assess the effect on OSA patients’ cardiovascular system.</p><p class="abstract"><strong>Methods:</strong> This is an observational study done on 32 individuals diagnosed with OSA after level I polysomnography from time period of January 01, 2018 to December 31, 2018. The blood coagulation parameters studied for each individual were platelet count, bleeding time (BT), activated partial thromboplastin time (aPTT) and prothrombin time (PT/INR).</p><p class="abstract"><strong>Results:</strong> Out of a total 32 subjects, 17 (53.13%) were male and 15 (46.87%) were female. There is a significant difference in mean prothrombin time (p=0.022). Kruskal-Wallis test showed a significant difference in the median of the PT/INR (p=0.01) and AHI (p<0.001) for different categories of OSA. Prothrombin time is the only factor which is affecting the OSA.</p><p class="abstract"><strong>Conclusions:</strong> Patients with severe OSA may have elevated coagulability levels, particularly in the length of prothrombin time. The potential for anticoagulant and antiplatelet medications to reduce mortality in patients with OSA merits exploration, particularly for patients who are unwilling or unable to achieve full control of OSA with currently available treatment options.</p>
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