Autism is a pervasive developmental disorder, with characteristics including impairments in reciprocal social interaction, impaired communication, and repetitive/stereotyped behaviors. Despite decades of research, the etiology of autism remains elusive. Thus, it is important that we pursue all avenues, in attempting to understand this complicated disorder. One such avenue is the development of animal models. While autism may be uniquely human, there are behavioral characteristics of the disorder that can be established in animal models. Evidence supports a genetic component for this disorder, and over the past few decades the mouse has been a highly valuable tool for the elucidation of pathways involved in many human disorders (e.g., Huntington's disease). As a first step toward establishing a mouse model of autism, we studied same-sex social behavior in a number of inbred mouse strains. In Study 1, we examined intra-strain social behavior of male pairs after one mouse had 15 minutes prior exposure to the testing chamber. In Study 2, we evaluated intra-strain and interstrain social behavior when both mice were naive to the testing chamber. The amount and type of social behavior seen differed between these studies, but overall there were general inbred strain differences in social behavior. Some strains were highly social (e.g., FVB/NJ, while others displayed low levels of social behavior (e.g., A/J, BTBR T+ tf/J). These strains may be useful in future genetic studies to determine specific genes involved in mouse social behavior, the findings of which should in turn help us to determine some of the genes involved in human social behavior and its disorders (e.g., autism).

Persephone is a NASA concept mission study that addresses key questions raised by New Horizons’ encounters with Kuiper Belt objects (KBOs), with arguably the most important being, “Does Pluto have a subsurface ocean?” More broadly, Persephone would answer four significant science questions: (1) What are the internal structures of Pluto and Charon? (2) How have the surfaces and atmospheres in the Pluto system evolved? (3) How has the KBO population evolved? (4) What are the particles and magnetic field environments of the Kuiper Belt? To answer these questions, Persephone has a comprehensive payload, and it would both orbit within the Pluto system and encounter other KBOs. The nominal mission is 30.7 yr long, with launch in 2031 on a Space Launch System Block 2 rocket with a Centaur kick stage, followed by a 27.6 yr cruise powered by existing radioisotope electric propulsion and a Jupiter gravity assist to reach Pluto in 2058. En route to Pluto, Persephone would have one 50–100 km class KBO encounter before starting a 3.1-Earth-year orbital campaign of the Pluto system. The mission also includes the potential for an 8 yr extended mission, which would enable the exploration of another KBO in the 100–150 km size class. The mission payload includes 11 instruments: Panchromatic and Color High-Resolution Imager, Low-Light Camera, Ultra-Violet Spectrometer, Near-Infrared (IR) Spectrometer, Thermal IR Camera, Radio Frequency Spectrometer, Mass Spectrometer, Altimeter, Sounding Radar, Magnetometer, and Plasma Spectrometer. The nominal cost of this mission is $3.0 billion, making it a large strategic science mission.